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- Publisher Website: 10.1038/nrc1412
- Scopus: eid_2-s2.0-3543092021
- PMID: 15286739
- WOS: WOS:000223039300012
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Article: Pathways of apoptotic and non-apoptotic death in tumour cells
Title | Pathways of apoptotic and non-apoptotic death in tumour cells |
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Authors | |
Issue Date | 2004 |
Citation | Nature Reviews Cancer, 2004, v. 4, n. 8, p. 592-603 How to Cite? |
Abstract | Defects in cell-death pathways are hallmarks of cancer. Although resistance to apoptosis is closely linked to tumorigenesis, tumour cells can still be induced to die by non-apoptotic mechanisms, such as necrosis, senescence, autophagy and mitotic catastrophe. The molecular pathways that underlie these non-apoptotic responses remain unclear. Several apoptotic and non-apoptotic pathways of cell death have been defined in normal physiology and during tumorigenesis, and these could potentially be manipulated to develop new cancer therapies. The mitotic-checkpoint molecule survivin - the inactivation of which induces the death of p53-deficient cells by mitotic catastrophe - is of particular interest. |
Persistent Identifier | http://hdl.handle.net/10722/291793 |
ISSN | 2023 Impact Factor: 72.5 2023 SCImago Journal Rankings: 26.837 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Okada, Hitoshi | - |
dc.contributor.author | Mak, Tak W. | - |
dc.date.accessioned | 2020-11-17T14:55:08Z | - |
dc.date.available | 2020-11-17T14:55:08Z | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Nature Reviews Cancer, 2004, v. 4, n. 8, p. 592-603 | - |
dc.identifier.issn | 1474-175X | - |
dc.identifier.uri | http://hdl.handle.net/10722/291793 | - |
dc.description.abstract | Defects in cell-death pathways are hallmarks of cancer. Although resistance to apoptosis is closely linked to tumorigenesis, tumour cells can still be induced to die by non-apoptotic mechanisms, such as necrosis, senescence, autophagy and mitotic catastrophe. The molecular pathways that underlie these non-apoptotic responses remain unclear. Several apoptotic and non-apoptotic pathways of cell death have been defined in normal physiology and during tumorigenesis, and these could potentially be manipulated to develop new cancer therapies. The mitotic-checkpoint molecule survivin - the inactivation of which induces the death of p53-deficient cells by mitotic catastrophe - is of particular interest. | - |
dc.language | eng | - |
dc.relation.ispartof | Nature Reviews Cancer | - |
dc.title | Pathways of apoptotic and non-apoptotic death in tumour cells | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1038/nrc1412 | - |
dc.identifier.pmid | 15286739 | - |
dc.identifier.scopus | eid_2-s2.0-3543092021 | - |
dc.identifier.volume | 4 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 592 | - |
dc.identifier.epage | 603 | - |
dc.identifier.isi | WOS:000223039300012 | - |
dc.identifier.issnl | 1474-175X | - |