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- Publisher Website: 10.1016/j.coi.2007.10.002
- Scopus: eid_2-s2.0-36849043810
- PMID: 18036806
- WOS: WOS:000252204600011
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Article: The role of E3 ligases in autoimmunity and the regulation of autoreactive T cells
Title | The role of E3 ligases in autoimmunity and the regulation of autoreactive T cells |
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Authors | |
Issue Date | 2007 |
Citation | Current Opinion in Immunology, 2007, v. 19, n. 6, p. 665-673 How to Cite? |
Abstract | The ubiquitination of proteins by E3 ligases has become an important regulatory mechanism for a variety of immune functions, including the maintenance of self tolerance and suppression of autoreactive T cell development. This review highlights recent advances in our knowledge of the functions in this context of known and potential E3 ligases, including autoimmune regulator (AIRE), TNF receptor-associated factor 6 (TRAF6), Casitas B cell lymphoma b (Cbl-b), gene related to anergy in lymphocytes (GRAIL), Itch, and Roquin. We discuss how disruptions to these molecules may contribute to the loss of T cell homeostasis and the pathogenesis of autoimmunity. We also report on the implications of the potential coordinated actions of these molecules for T cell anergy and regulatory T cell (Treg) functions. The great diversity of E3 ligases and the growing list of cellular processes in which ubiquitination plays a role make for an exciting field of research. Findings emerging from these investigations may suggest ways to exploit the therapeutic potential of manipulating ubiquitination, particularly for autoimmune disorders. © 2007. |
Persistent Identifier | http://hdl.handle.net/10722/291800 |
ISSN | 2023 Impact Factor: 6.6 2023 SCImago Journal Rankings: 2.841 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lin, Amy Erica | - |
dc.contributor.author | Mak, Tak W. | - |
dc.date.accessioned | 2020-11-17T14:55:08Z | - |
dc.date.available | 2020-11-17T14:55:08Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Current Opinion in Immunology, 2007, v. 19, n. 6, p. 665-673 | - |
dc.identifier.issn | 0952-7915 | - |
dc.identifier.uri | http://hdl.handle.net/10722/291800 | - |
dc.description.abstract | The ubiquitination of proteins by E3 ligases has become an important regulatory mechanism for a variety of immune functions, including the maintenance of self tolerance and suppression of autoreactive T cell development. This review highlights recent advances in our knowledge of the functions in this context of known and potential E3 ligases, including autoimmune regulator (AIRE), TNF receptor-associated factor 6 (TRAF6), Casitas B cell lymphoma b (Cbl-b), gene related to anergy in lymphocytes (GRAIL), Itch, and Roquin. We discuss how disruptions to these molecules may contribute to the loss of T cell homeostasis and the pathogenesis of autoimmunity. We also report on the implications of the potential coordinated actions of these molecules for T cell anergy and regulatory T cell (Treg) functions. The great diversity of E3 ligases and the growing list of cellular processes in which ubiquitination plays a role make for an exciting field of research. Findings emerging from these investigations may suggest ways to exploit the therapeutic potential of manipulating ubiquitination, particularly for autoimmune disorders. © 2007. | - |
dc.language | eng | - |
dc.relation.ispartof | Current Opinion in Immunology | - |
dc.title | The role of E3 ligases in autoimmunity and the regulation of autoreactive T cells | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.coi.2007.10.002 | - |
dc.identifier.pmid | 18036806 | - |
dc.identifier.scopus | eid_2-s2.0-36849043810 | - |
dc.identifier.volume | 19 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 665 | - |
dc.identifier.epage | 673 | - |
dc.identifier.isi | WOS:000252204600011 | - |
dc.identifier.issnl | 0952-7915 | - |