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- Publisher Website: 10.1038/nrm2434
- Scopus: eid_2-s2.0-45849085339
- PMID: 18568041
- WOS: WOS:000257073300012
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Article: Cytochrome c: Functions beyond respiration
| Title | Cytochrome c: Functions beyond respiration |
|---|---|
| Authors | |
| Issue Date | 2008 |
| Citation | Nature Reviews Molecular Cell Biology, 2008, v. 9, n. 7, p. 532-542 How to Cite? |
| Abstract | Cytochrome c is primarily known for its function in the mitochondria as a key participant in the life-supporting function of ATP synthesis. However, when a cell receives an apoptotic stimulus, cytochrome c is released into the cytosol and triggers programmed cell death through apoptosis. The release of cytochrome c and cytochrome-c-mediated apoptosis are controlled by multiple layers of regulation, the most prominent players being members of the B-cell lymphoma protein-2 (BCL2) family. As well as its role in canonical intrinsic apoptosis, cytochrome c amplifies signals that are generated by other apoptotic pathways and participates in certain non-apoptotic functions. © 2008 Macmillan Publishers Limited. All rights reserved. |
| Persistent Identifier | http://hdl.handle.net/10722/291833 |
| ISSN | 2021 Impact Factor: 113.915 2020 SCImago Journal Rankings: 37.461 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Ow, Yong Ling P. | - |
| dc.contributor.author | Green, Douglas R. | - |
| dc.contributor.author | Hao, Zhenyue | - |
| dc.contributor.author | Mak, Tak W. | - |
| dc.date.accessioned | 2020-11-17T14:55:12Z | - |
| dc.date.available | 2020-11-17T14:55:12Z | - |
| dc.date.issued | 2008 | - |
| dc.identifier.citation | Nature Reviews Molecular Cell Biology, 2008, v. 9, n. 7, p. 532-542 | - |
| dc.identifier.issn | 1471-0072 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/291833 | - |
| dc.description.abstract | Cytochrome c is primarily known for its function in the mitochondria as a key participant in the life-supporting function of ATP synthesis. However, when a cell receives an apoptotic stimulus, cytochrome c is released into the cytosol and triggers programmed cell death through apoptosis. The release of cytochrome c and cytochrome-c-mediated apoptosis are controlled by multiple layers of regulation, the most prominent players being members of the B-cell lymphoma protein-2 (BCL2) family. As well as its role in canonical intrinsic apoptosis, cytochrome c amplifies signals that are generated by other apoptotic pathways and participates in certain non-apoptotic functions. © 2008 Macmillan Publishers Limited. All rights reserved. | - |
| dc.language | eng | - |
| dc.relation.ispartof | Nature Reviews Molecular Cell Biology | - |
| dc.title | Cytochrome c: Functions beyond respiration | - |
| dc.type | Article | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.doi | 10.1038/nrm2434 | - |
| dc.identifier.pmid | 18568041 | - |
| dc.identifier.scopus | eid_2-s2.0-45849085339 | - |
| dc.identifier.volume | 9 | - |
| dc.identifier.issue | 7 | - |
| dc.identifier.spage | 532 | - |
| dc.identifier.epage | 542 | - |
| dc.identifier.eissn | 1471-0080 | - |
| dc.identifier.isi | WOS:000257073300012 | - |
| dc.identifier.issnl | 1471-0072 | - |