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Article: Apoptotic sensitivity of murine IAP-deficient cells

TitleApoptotic sensitivity of murine IAP-deficient cells
Authors
Rumble, Julie M.Bertrand, Mathieu J.M.Csomos, Rebecca A.Wright, Casey W.Albert, LoriMak, Tak W.Barker, Philip A.Duckett, Colin S.
KeywordsX-linked inhibitor of apoptosis (XIAP)
Apoptosis
Cellular inhibitor of apoptosis (c-IAP)
Murine fibroblast
Inhibitor of apoptosis protein (IAP)
Tumour necrosis factor (TNF)
Issue Date2008
Citation
Biochemical Journal, 2008, v. 415, n. 1, p. 21-25 How to Cite?
DOI: http://dx.doi.org/10.1042/BJ20081188
AbstractAlthough numerous studies have implicated the IAPs (inhibitor of apoptosis proteins) in the control of apoptotic cell death, analyses of murine Iap-targeted cells have not revealed significant differences in their susceptibility to apoptosis. In the present study, we show that, under defined conditions, murine cells lacking XIAP (X-linked inhibitor of apoptosis) and c-IAP (cellular IAP) 2, but not c-IAP1, exhibit heightened apoptotic sensitivity to both intrinsic and extrinsic apoptotic stimuli. © The Authors Journal compilation.
Persistent Identifierhttp://hdl.handle.net/10722/291858
ISSN
0264-6021
2023 Impact Factor: 4.4
2023 SCImago Journal Rankings: 1.612
ISI Accession Number ID
WOS:000259788300003

 

DC FieldValueLanguage
dc.contributor.authorRumble, Julie M.-
dc.contributor.authorBertrand, Mathieu J.M.-
dc.contributor.authorCsomos, Rebecca A.-
dc.contributor.authorWright, Casey W.-
dc.contributor.authorAlbert, Lori-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorBarker, Philip A.-
dc.contributor.authorDuckett, Colin S.-
dc.date.accessioned2020-11-17T14:55:15Z-
dc.date.available2020-11-17T14:55:15Z-
dc.date.issued2008-
dc.identifier.citationBiochemical Journal, 2008, v. 415, n. 1, p. 21-25-
dc.identifier.issn0264-6021-
dc.identifier.urihttp://hdl.handle.net/10722/291858-
dc.description.abstractAlthough numerous studies have implicated the IAPs (inhibitor of apoptosis proteins) in the control of apoptotic cell death, analyses of murine Iap-targeted cells have not revealed significant differences in their susceptibility to apoptosis. In the present study, we show that, under defined conditions, murine cells lacking XIAP (X-linked inhibitor of apoptosis) and c-IAP (cellular IAP) 2, but not c-IAP1, exhibit heightened apoptotic sensitivity to both intrinsic and extrinsic apoptotic stimuli. © The Authors Journal compilation.-
dc.languageeng-
dc.relation.ispartofBiochemical Journal-
dc.subjectX-linked inhibitor of apoptosis (XIAP)-
dc.subjectApoptosis-
dc.subjectCellular inhibitor of apoptosis (c-IAP)-
dc.subjectMurine fibroblast-
dc.subjectInhibitor of apoptosis protein (IAP)-
dc.subjectTumour necrosis factor (TNF)-
dc.titleApoptotic sensitivity of murine IAP-deficient cells-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1042/BJ20081188-
dc.identifier.pmid18684108-
dc.identifier.scopuseid_2-s2.0-53149121298-
dc.identifier.volume415-
dc.identifier.issue1-
dc.identifier.spage21-
dc.identifier.epage25-
dc.identifier.isiWOS:000259788300003-
dc.identifier.issnl0264-6021-

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