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- Publisher Website: 10.1016/j.cca.2008.08.022
- Scopus: eid_2-s2.0-54049090709
- PMID: 18801348
- WOS: WOS:000261074200023
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Article: Use of plasma DNA to predict mortality and need for intensive care in patients with abdominal pain
Title | Use of plasma DNA to predict mortality and need for intensive care in patients with abdominal pain |
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Authors | |
Keywords | ICU Acute abdominal pain Mortality Plasma DNA |
Issue Date | 2008 |
Citation | Clinica Chimica Acta, 2008, v. 398, n. 1-2, p. 113-117 How to Cite? |
Abstract | Background: We investigated the value of plasma deoxyribonucleic acid concentrations in patients presenting with acute abdominal pain to predict need for intensive care or mortality. Methods: Plasma deoxyribonucleic acid taken from patients with acute abdominal pain was analyzed for the β-globin gene using the quantitative polymerase chain reaction. The primary outcome measure was the combined 28-day mortality or admission to the intensive care unit. Results: Of 287 consecutive patients with acute abdominal pain recruited, 12 patients were admitted to the intensive care unit and/or died. Median plasma DNA concentrations were higher in patients with cancer and major organ inflammation. Mean plasma DNA concentrations were three-fold higher in patients with systemic inflammatory response syndrome, five-fold higher in patients who died within 28 days, and eight-fold higher in patients admitted to the intensive care unit. The area under the receiver operator curve for plasma DNA concentrations and intensive care unit admission/mortality was 0.804. At a cut-off of 1100 GE/ml, the sensitivity was 67% (95%CI 35-90) and specificity was 89% (95%CI 84-92). At a cut-off of 175 GE/ml, the sensitivity was 100% (95%CI 73-100) and specificity was 30% (95%CI 25-36). Plasma DNA concentration predicted need for intensive care unit admission or death (adjusted odds ratio 1.4; P < 0.0001). Conclusions: Plasma DNA may have a role in patients with acute abdominal pain as a marker for inflammation and cancer, and a predictor of intensive care unit admission/mortality. © 2008 Elsevier B.V. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/291864 |
ISSN | 2023 Impact Factor: 3.2 2023 SCImago Journal Rankings: 1.016 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Rainer, Timothy H. | - |
dc.contributor.author | Chan, Allen K.C. | - |
dc.contributor.author | Lee, Larry L.Y. | - |
dc.contributor.author | Yim, Veronica W.T. | - |
dc.contributor.author | Lam, Nicole Y.L. | - |
dc.contributor.author | Yeung, S. W. | - |
dc.contributor.author | Graham, Colin A. | - |
dc.contributor.author | Lo, Dennis Y.M. | - |
dc.date.accessioned | 2020-11-17T14:55:16Z | - |
dc.date.available | 2020-11-17T14:55:16Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Clinica Chimica Acta, 2008, v. 398, n. 1-2, p. 113-117 | - |
dc.identifier.issn | 0009-8981 | - |
dc.identifier.uri | http://hdl.handle.net/10722/291864 | - |
dc.description.abstract | Background: We investigated the value of plasma deoxyribonucleic acid concentrations in patients presenting with acute abdominal pain to predict need for intensive care or mortality. Methods: Plasma deoxyribonucleic acid taken from patients with acute abdominal pain was analyzed for the β-globin gene using the quantitative polymerase chain reaction. The primary outcome measure was the combined 28-day mortality or admission to the intensive care unit. Results: Of 287 consecutive patients with acute abdominal pain recruited, 12 patients were admitted to the intensive care unit and/or died. Median plasma DNA concentrations were higher in patients with cancer and major organ inflammation. Mean plasma DNA concentrations were three-fold higher in patients with systemic inflammatory response syndrome, five-fold higher in patients who died within 28 days, and eight-fold higher in patients admitted to the intensive care unit. The area under the receiver operator curve for plasma DNA concentrations and intensive care unit admission/mortality was 0.804. At a cut-off of 1100 GE/ml, the sensitivity was 67% (95%CI 35-90) and specificity was 89% (95%CI 84-92). At a cut-off of 175 GE/ml, the sensitivity was 100% (95%CI 73-100) and specificity was 30% (95%CI 25-36). Plasma DNA concentration predicted need for intensive care unit admission or death (adjusted odds ratio 1.4; P < 0.0001). Conclusions: Plasma DNA may have a role in patients with acute abdominal pain as a marker for inflammation and cancer, and a predictor of intensive care unit admission/mortality. © 2008 Elsevier B.V. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Clinica Chimica Acta | - |
dc.subject | ICU | - |
dc.subject | Acute abdominal pain | - |
dc.subject | Mortality | - |
dc.subject | Plasma DNA | - |
dc.title | Use of plasma DNA to predict mortality and need for intensive care in patients with abdominal pain | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.cca.2008.08.022 | - |
dc.identifier.pmid | 18801348 | - |
dc.identifier.scopus | eid_2-s2.0-54049090709 | - |
dc.identifier.volume | 398 | - |
dc.identifier.issue | 1-2 | - |
dc.identifier.spage | 113 | - |
dc.identifier.epage | 117 | - |
dc.identifier.isi | WOS:000261074200023 | - |
dc.identifier.issnl | 0009-8981 | - |