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- Publisher Website: 10.4049/jimmunol.0803282
- Scopus: eid_2-s2.0-65249089826
- PMID: 19342674
- WOS: WOS:000265004700057
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Article: Lipocalin 2 is required for pulmonary host defense against Klebsiella infection
Title | Lipocalin 2 is required for pulmonary host defense against Klebsiella infection |
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Authors | |
Issue Date | 2009 |
Citation | Journal of Immunology, 2009, v. 182, n. 8, p. 4947-4956 How to Cite? |
Abstract | Antimicrobial proteins comprise a significant component of the acute innate immune response to infection. They are induced by pattern recognition receptors as well as by cytokines of the innate and adaptive immune pathways and play important roles in infection control and immunomodulatory homeostasis. Lipocalin 2 (siderocalin, NGAL, 24p3), a siderophore-binding antimicrobial protein, is critical for control of systemic infection with Escherichia coli; however, its role in mucosal immunity in the respiratory tract is unknown. In this study, we found that lipocalin 2 is rapidly and robustly induced by Klebsiella pneumoniae infection and is TLR4 dependent. IL-1β and IL-17 also individually induce lipocalin 2. Mucosal administration of IL-1β alone could reconstitute the lipocalin 2 deficiency in TLR4 knockout animals and rescue them from infection. Lipocalin 2-deficient animals have impaired lung bacterial clearance in this model and mucosal reconstitution of lipocalin 2 protein in these animals resulted in rescue of this phenotype. We conclude that lipocalin 2 is a crucial component of mucosal immune defense against pulmonary infection with K. pneumoniae. Copyright © 2009 by The American Association of Immunologists, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/291888 |
ISSN | 2023 Impact Factor: 3.6 2023 SCImago Journal Rankings: 1.558 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chan, Yvonne R. | - |
dc.contributor.author | Liu, Jessica S. | - |
dc.contributor.author | Pociask, Derek A. | - |
dc.contributor.author | Zheng, Mingquan | - |
dc.contributor.author | Mietzner, Timothy A. | - |
dc.contributor.author | Berger, Thorsten | - |
dc.contributor.author | Mak, Tak W. | - |
dc.contributor.author | Clifton, Matthew C. | - |
dc.contributor.author | Strong, Roland K. | - |
dc.contributor.author | Ray, Prabir | - |
dc.contributor.author | Kolls, Jay K. | - |
dc.date.accessioned | 2020-11-17T14:55:19Z | - |
dc.date.available | 2020-11-17T14:55:19Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Journal of Immunology, 2009, v. 182, n. 8, p. 4947-4956 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | http://hdl.handle.net/10722/291888 | - |
dc.description.abstract | Antimicrobial proteins comprise a significant component of the acute innate immune response to infection. They are induced by pattern recognition receptors as well as by cytokines of the innate and adaptive immune pathways and play important roles in infection control and immunomodulatory homeostasis. Lipocalin 2 (siderocalin, NGAL, 24p3), a siderophore-binding antimicrobial protein, is critical for control of systemic infection with Escherichia coli; however, its role in mucosal immunity in the respiratory tract is unknown. In this study, we found that lipocalin 2 is rapidly and robustly induced by Klebsiella pneumoniae infection and is TLR4 dependent. IL-1β and IL-17 also individually induce lipocalin 2. Mucosal administration of IL-1β alone could reconstitute the lipocalin 2 deficiency in TLR4 knockout animals and rescue them from infection. Lipocalin 2-deficient animals have impaired lung bacterial clearance in this model and mucosal reconstitution of lipocalin 2 protein in these animals resulted in rescue of this phenotype. We conclude that lipocalin 2 is a crucial component of mucosal immune defense against pulmonary infection with K. pneumoniae. Copyright © 2009 by The American Association of Immunologists, Inc. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Immunology | - |
dc.title | Lipocalin 2 is required for pulmonary host defense against Klebsiella infection | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.4049/jimmunol.0803282 | - |
dc.identifier.pmid | 19342674 | - |
dc.identifier.pmcid | PMC2708928 | - |
dc.identifier.scopus | eid_2-s2.0-65249089826 | - |
dc.identifier.volume | 182 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 4947 | - |
dc.identifier.epage | 4956 | - |
dc.identifier.eissn | 1550-6606 | - |
dc.identifier.isi | WOS:000265004700057 | - |
dc.identifier.f1000 | 1160987 | - |
dc.identifier.issnl | 0022-1767 | - |