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- Publisher Website: 10.1038/nrm3086
- Scopus: eid_2-s2.0-79953058126
- PMID: 21427767
- WOS: WOS:000288696700013
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Article: The p53 family: Guardians of maternal reproduction
Title | The p53 family: Guardians of maternal reproduction |
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Authors | |
Issue Date | 2011 |
Citation | Nature Reviews Molecular Cell Biology, 2011, v. 12, n. 4, p. 259-265 How to Cite? |
Abstract | The p53 family of proteins consists of p53, p63 and p73, which are transcription factors that affect both cancer and development. It is now emerging that these proteins also regulate maternal reproduction. Whereas p63 is important for maturation of the egg, p73 ensures normal mitosis in the developing blastocyst. p53 subsequently regulates implantation of the embryo through transcriptional control of leukaemia inhibitory factor. Elucidating the cell biological basis of how these factors regulate female fertility may lead to new approaches to the control of human maternal reproduction. © 2011 Macmillan Publishers Limited. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/292022 |
ISSN | 2023 Impact Factor: 81.3 2023 SCImago Journal Rankings: 35.910 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Levine, Arnold J. | - |
dc.contributor.author | Tomasini, Richard | - |
dc.contributor.author | McKeon, Frank D. | - |
dc.contributor.author | Mak, Tak W. | - |
dc.contributor.author | Melino, Gerry | - |
dc.date.accessioned | 2020-11-17T14:55:36Z | - |
dc.date.available | 2020-11-17T14:55:36Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Nature Reviews Molecular Cell Biology, 2011, v. 12, n. 4, p. 259-265 | - |
dc.identifier.issn | 1471-0072 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292022 | - |
dc.description.abstract | The p53 family of proteins consists of p53, p63 and p73, which are transcription factors that affect both cancer and development. It is now emerging that these proteins also regulate maternal reproduction. Whereas p63 is important for maturation of the egg, p73 ensures normal mitosis in the developing blastocyst. p53 subsequently regulates implantation of the embryo through transcriptional control of leukaemia inhibitory factor. Elucidating the cell biological basis of how these factors regulate female fertility may lead to new approaches to the control of human maternal reproduction. © 2011 Macmillan Publishers Limited. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Nature Reviews Molecular Cell Biology | - |
dc.title | The p53 family: Guardians of maternal reproduction | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1038/nrm3086 | - |
dc.identifier.pmid | 21427767 | - |
dc.identifier.scopus | eid_2-s2.0-79953058126 | - |
dc.identifier.volume | 12 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 259 | - |
dc.identifier.epage | 265 | - |
dc.identifier.eissn | 1471-0080 | - |
dc.identifier.isi | WOS:000288696700013 | - |
dc.identifier.issnl | 1471-0072 | - |