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Book Chapter: Pathophysiological Roles and Clinical Importance of Biomarkers in Acute Coronary Syndrome

TitlePathophysiological Roles and Clinical Importance of Biomarkers in Acute Coronary Syndrome
Authors
Issue Date2013
PublisherAcademic Press.
Citation
Pathophysiological Roles and Clinical Importance of Biomarkers in Acute Coronary Syndrome. In Makowski, GS (Ed.), Advances in Clinical Chemistry, Volume 59, p. 23-63. San Diego, CA: Academic Press, 2013 How to Cite?
AbstractEarly diagnosis of acute coronary syndrome (ACS) is important to guide appropriate therapy at a time when it is most likely to be of value. Accurate prognostic and risk stratification will facilitate high-risk patients to have early advanced diagnostic investigations and early appropriate interventions in a cost-effective and efficient manner, while those patients at low risk of ACS complications do not need such costly diagnostic tests and unnecessary hospital admission. Recent investigations have demonstrated that elevation of biomarkers upstream from acute-phase biomarkers, biomarkers of plaque destabilization and rupture, biomarkers of myocardial ischemia, necrosis, and dysfunction may provide an earlier assessment of patient risk and identify patients with higher risk of having an adverse event. This review provides an overview of the pathophysiology and clinical characteristics of several well-established biomarkers as well as emerging biomarkers that may have potential clinical utility in patients with ACS. Such emerging biomarkers hold promise and need to be more thoroughly evaluated before utilization in routine clinical practice.
Persistent Identifierhttp://hdl.handle.net/10722/292029
ISBN
ISSN
2019 Impact Factor: 3.367
2015 SCImago Journal Rankings: 0.938
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, CPY-
dc.contributor.authorRainer, TH-
dc.date.accessioned2020-11-17T14:55:37Z-
dc.date.available2020-11-17T14:55:37Z-
dc.date.issued2013-
dc.identifier.citationPathophysiological Roles and Clinical Importance of Biomarkers in Acute Coronary Syndrome. In Makowski, GS (Ed.), Advances in Clinical Chemistry, Volume 59, p. 23-63. San Diego, CA: Academic Press, 2013-
dc.identifier.isbn9780124052116-
dc.identifier.issn0065-2423-
dc.identifier.urihttp://hdl.handle.net/10722/292029-
dc.description.abstractEarly diagnosis of acute coronary syndrome (ACS) is important to guide appropriate therapy at a time when it is most likely to be of value. Accurate prognostic and risk stratification will facilitate high-risk patients to have early advanced diagnostic investigations and early appropriate interventions in a cost-effective and efficient manner, while those patients at low risk of ACS complications do not need such costly diagnostic tests and unnecessary hospital admission. Recent investigations have demonstrated that elevation of biomarkers upstream from acute-phase biomarkers, biomarkers of plaque destabilization and rupture, biomarkers of myocardial ischemia, necrosis, and dysfunction may provide an earlier assessment of patient risk and identify patients with higher risk of having an adverse event. This review provides an overview of the pathophysiology and clinical characteristics of several well-established biomarkers as well as emerging biomarkers that may have potential clinical utility in patients with ACS. Such emerging biomarkers hold promise and need to be more thoroughly evaluated before utilization in routine clinical practice.-
dc.languageeng-
dc.publisherAcademic Press.-
dc.relation.ispartofAdvances in Clinical Chemistry, Volume 59-
dc.titlePathophysiological Roles and Clinical Importance of Biomarkers in Acute Coronary Syndrome-
dc.typeBook_Chapter-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/B978-0-12-405211-6.00002-4-
dc.identifier.pmid23461132-
dc.identifier.scopuseid_2-s2.0-84870991182-
dc.identifier.spage23-
dc.identifier.epage63-
dc.identifier.isiWOS:000314141100003-
dc.publisher.placeSan Diego, CA-
dc.identifier.issnl0065-2423-

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