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- Publisher Website: 10.1016/j.tcb.2015.12.002
- Scopus: eid_2-s2.0-84954285142
- PMID: 26791157
- WOS: WOS:000374198200003
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Article: TNF and ROS Crosstalk in Inflammation
Title | TNF and ROS Crosstalk in Inflammation |
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Authors | |
Keywords | NADPH oxidase (NOX) Necroptosis Inflammation Immunity Reactive oxygen species (ROS) Tumor necrosis factor (TNF) |
Issue Date | 2016 |
Citation | Trends in Cell Biology, 2016, v. 26, n. 4, p. 249-261 How to Cite? |
Abstract | © 2015 Elsevier Ltd. Tumor necrosis factor (TNF) is tremendously important for mammalian immunity and cellular homeostasis. The role of TNF as a master regulator in balancing cell survival, apoptosis and necroptosis has been extensively studied in various cell types and tissues. Although these findings have revealed much about the direct impact of TNF on the regulation of NF-κB and JNK, there is now rising interest in understanding the emerging function of TNF as a regulator of the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). In this review we summarize work aimed at defining the role of TNF in the control of ROS/RNS signaling that influences innate immune cells under both physiological and inflammatory conditions. |
Persistent Identifier | http://hdl.handle.net/10722/292061 |
ISSN | 2023 Impact Factor: 13.0 2023 SCImago Journal Rankings: 6.002 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Blaser, Heiko | - |
dc.contributor.author | Dostert, Catherine | - |
dc.contributor.author | Mak, Tak W. | - |
dc.contributor.author | Brenner, Dirk | - |
dc.date.accessioned | 2020-11-17T14:55:41Z | - |
dc.date.available | 2020-11-17T14:55:41Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Trends in Cell Biology, 2016, v. 26, n. 4, p. 249-261 | - |
dc.identifier.issn | 0962-8924 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292061 | - |
dc.description.abstract | © 2015 Elsevier Ltd. Tumor necrosis factor (TNF) is tremendously important for mammalian immunity and cellular homeostasis. The role of TNF as a master regulator in balancing cell survival, apoptosis and necroptosis has been extensively studied in various cell types and tissues. Although these findings have revealed much about the direct impact of TNF on the regulation of NF-κB and JNK, there is now rising interest in understanding the emerging function of TNF as a regulator of the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). In this review we summarize work aimed at defining the role of TNF in the control of ROS/RNS signaling that influences innate immune cells under both physiological and inflammatory conditions. | - |
dc.language | eng | - |
dc.relation.ispartof | Trends in Cell Biology | - |
dc.subject | NADPH oxidase (NOX) | - |
dc.subject | Necroptosis | - |
dc.subject | Inflammation | - |
dc.subject | Immunity | - |
dc.subject | Reactive oxygen species (ROS) | - |
dc.subject | Tumor necrosis factor (TNF) | - |
dc.title | TNF and ROS Crosstalk in Inflammation | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.tcb.2015.12.002 | - |
dc.identifier.pmid | 26791157 | - |
dc.identifier.scopus | eid_2-s2.0-84954285142 | - |
dc.identifier.volume | 26 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 249 | - |
dc.identifier.epage | 261 | - |
dc.identifier.eissn | 1879-3088 | - |
dc.identifier.isi | WOS:000374198200003 | - |
dc.identifier.issnl | 0962-8924 | - |