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Article: Glutathione Metabolism: An Achilles’ Heel of ARID1A-Deficient Tumors

TitleGlutathione Metabolism: An Achilles’ Heel of ARID1A-Deficient Tumors
Authors
Gorrini, ChiaraMak, Tak W.
Issue Date2019
Citation
Cancer Cell, 2019, v. 35, n. 2, p. 161-163 How to Cite?
DOI: http://dx.doi.org/10.1016/j.ccell.2019.01.017
Abstract© 2019 Elsevier Inc. In this issue of Cancer Cell, Ogiwara et al. describe a novel link between the epigenetic regulator ARID1A and glutathione metabolism in cancer that is mediated by regulation of the cystine/glutamate transporter XCT. This work reveals that synthesis of reduced glutathione is a metabolic dependency of cancers with ARID1A-inactivating mutations.
Persistent Identifierhttp://hdl.handle.net/10722/292101
ISSN
1535-6108
2021 Impact Factor: 38.585
2020 SCImago Journal Rankings: 13.035
ISI Accession Number ID
WOS:000458295100002

 

DC FieldValueLanguage
dc.contributor.authorGorrini, Chiara-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:55:46Z-
dc.date.available2020-11-17T14:55:46Z-
dc.date.issued2019-
dc.identifier.citationCancer Cell, 2019, v. 35, n. 2, p. 161-163-
dc.identifier.issn1535-6108-
dc.identifier.urihttp://hdl.handle.net/10722/292101-
dc.description.abstract© 2019 Elsevier Inc. In this issue of Cancer Cell, Ogiwara et al. describe a novel link between the epigenetic regulator ARID1A and glutathione metabolism in cancer that is mediated by regulation of the cystine/glutamate transporter XCT. This work reveals that synthesis of reduced glutathione is a metabolic dependency of cancers with ARID1A-inactivating mutations.-
dc.languageeng-
dc.relation.ispartofCancer Cell-
dc.titleGlutathione Metabolism: An Achilles’ Heel of ARID1A-Deficient Tumors-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.ccell.2019.01.017-
dc.identifier.pmid30753819-
dc.identifier.scopuseid_2-s2.0-85060754507-
dc.identifier.volume35-
dc.identifier.issue2-
dc.identifier.spage161-
dc.identifier.epage163-
dc.identifier.eissn1878-3686-
dc.identifier.isiWOS:000458295100002-
dc.identifier.issnl1535-6108-

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