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- Publisher Website: 10.1016/j.ccell.2019.01.017
- Scopus: eid_2-s2.0-85060754507
- PMID: 30753819
- WOS: WOS:000458295100002
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Article: Glutathione Metabolism: An Achilles’ Heel of ARID1A-Deficient Tumors
Title | Glutathione Metabolism: An Achilles’ Heel of ARID1A-Deficient Tumors |
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Authors | |
Issue Date | 2019 |
Citation | Cancer Cell, 2019, v. 35, n. 2, p. 161-163 How to Cite? |
Abstract | © 2019 Elsevier Inc. In this issue of Cancer Cell, Ogiwara et al. describe a novel link between the epigenetic regulator ARID1A and glutathione metabolism in cancer that is mediated by regulation of the cystine/glutamate transporter XCT. This work reveals that synthesis of reduced glutathione is a metabolic dependency of cancers with ARID1A-inactivating mutations. |
Persistent Identifier | http://hdl.handle.net/10722/292101 |
ISSN | 2023 Impact Factor: 48.8 2023 SCImago Journal Rankings: 17.507 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Gorrini, Chiara | - |
dc.contributor.author | Mak, Tak W. | - |
dc.date.accessioned | 2020-11-17T14:55:46Z | - |
dc.date.available | 2020-11-17T14:55:46Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Cancer Cell, 2019, v. 35, n. 2, p. 161-163 | - |
dc.identifier.issn | 1535-6108 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292101 | - |
dc.description.abstract | © 2019 Elsevier Inc. In this issue of Cancer Cell, Ogiwara et al. describe a novel link between the epigenetic regulator ARID1A and glutathione metabolism in cancer that is mediated by regulation of the cystine/glutamate transporter XCT. This work reveals that synthesis of reduced glutathione is a metabolic dependency of cancers with ARID1A-inactivating mutations. | - |
dc.language | eng | - |
dc.relation.ispartof | Cancer Cell | - |
dc.title | Glutathione Metabolism: An Achilles’ Heel of ARID1A-Deficient Tumors | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1016/j.ccell.2019.01.017 | - |
dc.identifier.pmid | 30753819 | - |
dc.identifier.scopus | eid_2-s2.0-85060754507 | - |
dc.identifier.volume | 35 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 161 | - |
dc.identifier.epage | 163 | - |
dc.identifier.eissn | 1878-3686 | - |
dc.identifier.isi | WOS:000458295100002 | - |
dc.identifier.issnl | 1535-6108 | - |