File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1038/s41467-019-10619-w
- Scopus: eid_2-s2.0-85067544135
- PMID: 31213601
- WOS: WOS:000471872000001
Supplementary
- Citations:
- Appears in Collections:
Article: Fcmr regulates mononuclear phagocyte control of anti-tumor immunity
Title | Fcmr regulates mononuclear phagocyte control of anti-tumor immunity |
---|---|
Authors | |
Issue Date | 2019 |
Citation | Nature Communications, 2019, v. 10, n. 1, article no. 2678 How to Cite? |
Abstract | Myeloid cells contribute to tumor progression, but how the constellation of receptors they express regulates their functions within the tumor microenvironment (TME) is unclear. We demonstrate that Fcmr (Toso), the putative receptor for soluble IgM, modulates myeloid cell responses to cancer. In a syngeneic melanoma model, Fcmr ablation in myeloid cells suppressed tumor growth and extended mouse survival. Fcmr deficiency increased myeloid cell population density in this malignancy and enhanced anti-tumor immunity. Single-cell RNA sequencing of Fcmr-deficient tumor-associated mononuclear phagocytes revealed a unique subset with enhanced antigen processing/presenting properties. Conversely, Fcmr activity negatively regulated the activation and migratory capacity of myeloid cells in vivo, and T cell activation by bone marrow-derived dendritic cells in vitro. Therapeutic targeting of Fcmr during oncogenesis decreased tumor growth when used as a single agent or in combination with anti-PD-1. Thus, Fcmr regulates myeloid cell activation within the TME and may be a potential therapeutic target. |
Persistent Identifier | http://hdl.handle.net/10722/292116 |
PubMed Central ID | |
ISI Accession Number ID | |
Errata |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kubli, Shawn P. | - |
dc.contributor.author | Vornholz, Larsen | - |
dc.contributor.author | Duncan, Gordon | - |
dc.contributor.author | Zhou, Wenjing | - |
dc.contributor.author | Ramachandran, Parameswaran | - |
dc.contributor.author | Fortin, Jerome | - |
dc.contributor.author | Cox, Maureen | - |
dc.contributor.author | Han, Seong Jun | - |
dc.contributor.author | Nechanitzky, Robert | - |
dc.contributor.author | Nechanitzky, Duygu | - |
dc.contributor.author | Snow, Bryan E. | - |
dc.contributor.author | Jones, Lisa | - |
dc.contributor.author | Li, Wanda Y. | - |
dc.contributor.author | Haight, Jillian | - |
dc.contributor.author | Wakeham, Andrew | - |
dc.contributor.author | Bray, Mark R. | - |
dc.contributor.author | Mak, Tak W. | - |
dc.date.accessioned | 2020-11-17T14:55:48Z | - |
dc.date.available | 2020-11-17T14:55:48Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Nature Communications, 2019, v. 10, n. 1, article no. 2678 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292116 | - |
dc.description.abstract | Myeloid cells contribute to tumor progression, but how the constellation of receptors they express regulates their functions within the tumor microenvironment (TME) is unclear. We demonstrate that Fcmr (Toso), the putative receptor for soluble IgM, modulates myeloid cell responses to cancer. In a syngeneic melanoma model, Fcmr ablation in myeloid cells suppressed tumor growth and extended mouse survival. Fcmr deficiency increased myeloid cell population density in this malignancy and enhanced anti-tumor immunity. Single-cell RNA sequencing of Fcmr-deficient tumor-associated mononuclear phagocytes revealed a unique subset with enhanced antigen processing/presenting properties. Conversely, Fcmr activity negatively regulated the activation and migratory capacity of myeloid cells in vivo, and T cell activation by bone marrow-derived dendritic cells in vitro. Therapeutic targeting of Fcmr during oncogenesis decreased tumor growth when used as a single agent or in combination with anti-PD-1. Thus, Fcmr regulates myeloid cell activation within the TME and may be a potential therapeutic target. | - |
dc.language | eng | - |
dc.relation.ispartof | Nature Communications | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Fcmr regulates mononuclear phagocyte control of anti-tumor immunity | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/s41467-019-10619-w | - |
dc.identifier.pmid | 31213601 | - |
dc.identifier.pmcid | PMC6581943 | - |
dc.identifier.scopus | eid_2-s2.0-85067544135 | - |
dc.identifier.volume | 10 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | article no. 2678 | - |
dc.identifier.epage | article no. 2678 | - |
dc.identifier.eissn | 2041-1723 | - |
dc.identifier.isi | WOS:000471872000001 | - |
dc.relation.erratum | doi:10.1038/s41467-019-12106-8 | - |
dc.relation.erratum | eid:eid_2-s2.0-85071753616 | - |
dc.identifier.issnl | 2041-1723 | - |