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Article: Impaired olfactory identification and hedonic judgment in schizophrenia patients with prominent negative symptoms

TitleImpaired olfactory identification and hedonic judgment in schizophrenia patients with prominent negative symptoms
Authors
Keywordsanhedonia
schizophrenia
Olfaction
hedonic judgement
Issue Date2020
Citation
Cognitive Neuropsychiatry, 2020, v. 25, n. 2, p. 126-138 How to Cite?
Abstract© 2019 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Evidence suggests that schizophrenia patients have olfactory dysfunctions, but the relationship between olfactory identification, hedonic judgement, and negative symptomatology remains unclear. Few studies have investigated whether co-activation of pleasant and unpleasant emotions are more prevalent in schizophrenia patients. Methods: Thirty schizophrenia outpatients with prominent negative symptoms (PNS), 30 outpatients without PNS, and 30 controls completed the University of Pennsylvania Smell Identification Test, and were asked to identify the odourants and to rate their emotions. The effects of gender and medications on olfactory function were examined. Results: Schizophrenia patients exhibited olfactory identification impairments, even after accounting for gender and medication effects. Patients with PNS demonstrated larger magnitude of deficit than those without. Patients with PNS reported less pleasure to positive-valenced odourants, and less unpleasantness to negative-valenced odourants than controls. Olfactory anhedonia in patients with PNS disappeared after controlling for medication effect. Schizophrenia patients do not exhibit affective ambivalence in olfaction. Conclusions: Schizophrenia patients with PNS exhibit deficits in olfactory identification and hedonic judgement, even after controlling for gender and medication effects. Our findings support the close relationship between olfactory dysfunctions and negative symptoms. Further studies should investigate the effect of dopamine-blocking agents on the olfactory hedonic judgment in schizophrenia patients.
Persistent Identifierhttp://hdl.handle.net/10722/292139
ISSN
2023 Impact Factor: 1.5
2023 SCImago Journal Rankings: 0.680
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLui, Simon S.Y.-
dc.contributor.authorChiu, Mindi W.Y.-
dc.contributor.authorChui, William W.H.-
dc.contributor.authorWong, Jessica O.Y.-
dc.contributor.authorMan, Cappy M.Y.-
dc.contributor.authorCheung, Eric F.C.-
dc.contributor.authorChan, Raymond C.K.-
dc.date.accessioned2020-11-17T14:55:51Z-
dc.date.available2020-11-17T14:55:51Z-
dc.date.issued2020-
dc.identifier.citationCognitive Neuropsychiatry, 2020, v. 25, n. 2, p. 126-138-
dc.identifier.issn1354-6805-
dc.identifier.urihttp://hdl.handle.net/10722/292139-
dc.description.abstract© 2019 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Evidence suggests that schizophrenia patients have olfactory dysfunctions, but the relationship between olfactory identification, hedonic judgement, and negative symptomatology remains unclear. Few studies have investigated whether co-activation of pleasant and unpleasant emotions are more prevalent in schizophrenia patients. Methods: Thirty schizophrenia outpatients with prominent negative symptoms (PNS), 30 outpatients without PNS, and 30 controls completed the University of Pennsylvania Smell Identification Test, and were asked to identify the odourants and to rate their emotions. The effects of gender and medications on olfactory function were examined. Results: Schizophrenia patients exhibited olfactory identification impairments, even after accounting for gender and medication effects. Patients with PNS demonstrated larger magnitude of deficit than those without. Patients with PNS reported less pleasure to positive-valenced odourants, and less unpleasantness to negative-valenced odourants than controls. Olfactory anhedonia in patients with PNS disappeared after controlling for medication effect. Schizophrenia patients do not exhibit affective ambivalence in olfaction. Conclusions: Schizophrenia patients with PNS exhibit deficits in olfactory identification and hedonic judgement, even after controlling for gender and medication effects. Our findings support the close relationship between olfactory dysfunctions and negative symptoms. Further studies should investigate the effect of dopamine-blocking agents on the olfactory hedonic judgment in schizophrenia patients.-
dc.languageeng-
dc.relation.ispartofCognitive Neuropsychiatry-
dc.subjectanhedonia-
dc.subjectschizophrenia-
dc.subjectOlfaction-
dc.subjecthedonic judgement-
dc.titleImpaired olfactory identification and hedonic judgment in schizophrenia patients with prominent negative symptoms-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/13546805.2019.1704709-
dc.identifier.pmid31856651-
dc.identifier.scopuseid_2-s2.0-85076902380-
dc.identifier.hkuros318751-
dc.identifier.volume25-
dc.identifier.issue2-
dc.identifier.spage126-
dc.identifier.epage138-
dc.identifier.eissn1464-0619-
dc.identifier.isiWOS:000503710000001-
dc.identifier.issnl1354-6805-

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