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- Publisher Website: 10.3389/fimmu.2020.00450
- Scopus: eid_2-s2.0-85082693557
- PMID: 32231671
- WOS: WOS:000525549300001
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Article: ANP32B Deficiency Protects Mice From Lethal Influenza A Virus Challenge by Dampening the Host Immune Response
Title | ANP32B Deficiency Protects Mice From Lethal Influenza A Virus Challenge by Dampening the Host Immune Response |
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Authors | |
Keywords | pathogenesis influenza A virus ANP32B antiviral immunity ANP32A |
Issue Date | 2020 |
Citation | Frontiers in Immunology, 2020, v. 11, article no. 450 How to Cite? |
Abstract | Deciphering complex virus-host interactions is crucial for pandemic preparedness. In this study, we assessed the impact of recently postulated cellular factors ANP32A and ANP32B of influenza A virus (IAV) species specificity on viral pathogenesis in a genetically modified mouse model. Infection of ANP32A−/− and ANP32A+/+ mice with a seasonal H3N2 IAV or a highly pathogenic H5N1 human isolate did not result in any significant differences in virus tropism, innate immune response or disease outcome. However, infection of ANP32B−/− mice with H3N2 or H5N1 IAV revealed significantly reduced virus loads, inflammatory cytokine response and reduced pathogenicity compared to ANP32B+/+ mice. Genome-wide transcriptome analyses in ANP32B+/+ and ANP32B−/− mice further uncovered novel immune-regulatory pathways that correlate with reduced pathogenicity in the absence of ANP32B. These data show that ANP32B but not ANP32A promotes IAV pathogenesis in mice. Moreover, ANP32B might possess a yet unknown immune-modulatory function during IAV infection. Targeting ANP32B or its regulated pathways might therefore pose a new strategy to combat severe influenza. |
Persistent Identifier | http://hdl.handle.net/10722/292151 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Beck, Sebastian | - |
dc.contributor.author | Zickler, Martin | - |
dc.contributor.author | Pinho dos Reis, Vinícius | - |
dc.contributor.author | Günther, Thomas | - |
dc.contributor.author | Grundhoff, Adam | - |
dc.contributor.author | Reilly, Patrick T. | - |
dc.contributor.author | Mak, Tak W. | - |
dc.contributor.author | Stanelle-Bertram, Stephanie | - |
dc.contributor.author | Gabriel, Gülşah | - |
dc.date.accessioned | 2020-11-17T14:55:52Z | - |
dc.date.available | 2020-11-17T14:55:52Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Frontiers in Immunology, 2020, v. 11, article no. 450 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292151 | - |
dc.description.abstract | Deciphering complex virus-host interactions is crucial for pandemic preparedness. In this study, we assessed the impact of recently postulated cellular factors ANP32A and ANP32B of influenza A virus (IAV) species specificity on viral pathogenesis in a genetically modified mouse model. Infection of ANP32A−/− and ANP32A+/+ mice with a seasonal H3N2 IAV or a highly pathogenic H5N1 human isolate did not result in any significant differences in virus tropism, innate immune response or disease outcome. However, infection of ANP32B−/− mice with H3N2 or H5N1 IAV revealed significantly reduced virus loads, inflammatory cytokine response and reduced pathogenicity compared to ANP32B+/+ mice. Genome-wide transcriptome analyses in ANP32B+/+ and ANP32B−/− mice further uncovered novel immune-regulatory pathways that correlate with reduced pathogenicity in the absence of ANP32B. These data show that ANP32B but not ANP32A promotes IAV pathogenesis in mice. Moreover, ANP32B might possess a yet unknown immune-modulatory function during IAV infection. Targeting ANP32B or its regulated pathways might therefore pose a new strategy to combat severe influenza. | - |
dc.language | eng | - |
dc.relation.ispartof | Frontiers in Immunology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | pathogenesis | - |
dc.subject | influenza A virus | - |
dc.subject | ANP32B | - |
dc.subject | antiviral immunity | - |
dc.subject | ANP32A | - |
dc.title | ANP32B Deficiency Protects Mice From Lethal Influenza A Virus Challenge by Dampening the Host Immune Response | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3389/fimmu.2020.00450 | - |
dc.identifier.pmid | 32231671 | - |
dc.identifier.pmcid | PMC7083139 | - |
dc.identifier.scopus | eid_2-s2.0-85082693557 | - |
dc.identifier.volume | 11 | - |
dc.identifier.spage | article no. 450 | - |
dc.identifier.epage | article no. 450 | - |
dc.identifier.eissn | 1664-3224 | - |
dc.identifier.isi | WOS:000525549300001 | - |
dc.identifier.issnl | 1664-3224 | - |