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Article: Analysis of molecular events in leukemic cells arrested at an early stage of T-cell differentiation

TitleAnalysis of molecular events in leukemic cells arrested at an early stage of T-cell differentiation
Authors
Issue Date1989
Citation
Blood, 1989, v. 74, n. 6, p. 2103-2111 How to Cite?
AbstractWe analyzed the rearrangement and expression of T-cell receptor (TCR) genes, including the recently identified TCRδ gene, in 21 patients with T-lineage leukemia/lymphoma. Among 8 patients with CD3-, CD4-, and CD8- (group I), 2 patients showed germline configuration of the TCRδ, γ, β, and α genes and 1 patient demonstrated only TCRδ gene rearrangement. All nine patients with CD3-, CD4+, and/or CD8+ (group II) showed concomitant rearrangements of the TCRδ, γ, and β genes. TCRα gene rearrangement was also observed in two patients. Three of four patients with CD3+ (group III) showed rearrangement of the TCRα gene with deletion of both alleles or of a single allele of the TCRδ gene. With Northern blot analysis, full-length transcripts of the TCRδ gene were detected in 3 of 15 examined patients. All were restricted to group I or group II. In contrast, full-length transcripts of TCRβ and α were observed mainly in samples from groups II and III. Based on these findings, rearrangement of the TCRδ gene may be the earliest event in T-cell differentiation, preceding rearrangement of the other TCR genes.
Persistent Identifierhttp://hdl.handle.net/10722/292165
ISSN
2023 Impact Factor: 21.0
2023 SCImago Journal Rankings: 5.272
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYumura-Yagi, K.-
dc.contributor.authorHara, J.-
dc.contributor.authorTerada, N.-
dc.contributor.authorIshihara, S.-
dc.contributor.authorTawa, A.-
dc.contributor.authorTakihara, Y.-
dc.contributor.authorChampagne, E.-
dc.contributor.authorMinden, M. D.-
dc.contributor.authorMak, T. W.-
dc.contributor.authorKawa-Ha, K.-
dc.date.accessioned2020-11-17T14:55:54Z-
dc.date.available2020-11-17T14:55:54Z-
dc.date.issued1989-
dc.identifier.citationBlood, 1989, v. 74, n. 6, p. 2103-2111-
dc.identifier.issn0006-4971-
dc.identifier.urihttp://hdl.handle.net/10722/292165-
dc.description.abstractWe analyzed the rearrangement and expression of T-cell receptor (TCR) genes, including the recently identified TCRδ gene, in 21 patients with T-lineage leukemia/lymphoma. Among 8 patients with CD3-, CD4-, and CD8- (group I), 2 patients showed germline configuration of the TCRδ, γ, β, and α genes and 1 patient demonstrated only TCRδ gene rearrangement. All nine patients with CD3-, CD4+, and/or CD8+ (group II) showed concomitant rearrangements of the TCRδ, γ, and β genes. TCRα gene rearrangement was also observed in two patients. Three of four patients with CD3+ (group III) showed rearrangement of the TCRα gene with deletion of both alleles or of a single allele of the TCRδ gene. With Northern blot analysis, full-length transcripts of the TCRδ gene were detected in 3 of 15 examined patients. All were restricted to group I or group II. In contrast, full-length transcripts of TCRβ and α were observed mainly in samples from groups II and III. Based on these findings, rearrangement of the TCRδ gene may be the earliest event in T-cell differentiation, preceding rearrangement of the other TCR genes.-
dc.languageeng-
dc.relation.ispartofBlood-
dc.titleAnalysis of molecular events in leukemic cells arrested at an early stage of T-cell differentiation-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1182/blood.v74.6.2103.2103-
dc.identifier.pmid2553161-
dc.identifier.scopuseid_2-s2.0-0024436225-
dc.identifier.volume74-
dc.identifier.issue6-
dc.identifier.spage2103-
dc.identifier.epage2111-
dc.identifier.isiWOS:A1989AX04400037-
dc.identifier.issnl0006-4971-

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