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Article: Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice
Title | Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice |
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Authors | |
Issue Date | 1996 |
Citation | Cancer Research, 1996, v. 56, n. 16, p. 3842-3849 How to Cite? |
Abstract | Hereditary nonpolyposis colorectal cancer is associated with defects in DNA mismatch repair. Here, we characterize tumor susceptibility of the recently described Msh2-deficient mouse model. Within the first year of observation, all homozygous mice succumbed to disease, with lymphomas observed in at least 80% of the cases. The majority (70%) of animals 6 months or older developed intestinal neoplasms associated with APC inactivation. Microsatellite instability was more common in carcinomas than in adenomas, but uncommon in normal tissues. Some animals (7%) developed a variety of skin neoplasms analogous to the Muir-Torre syndrome. Msh2(-/-) mice implicate a direct role for mismatch repair in several neoplasms with striking phenotypic similarities to humans. |
Persistent Identifier | http://hdl.handle.net/10722/292228 |
ISSN | 2021 Impact Factor: 13.312 2020 SCImago Journal Rankings: 4.103 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Reitmair, Armin H. | - |
dc.contributor.author | Redston, Mark | - |
dc.contributor.author | Cai, Jian Chun | - |
dc.contributor.author | Chuang, Tony C.Y. | - |
dc.contributor.author | Bjerknes, Matthew | - |
dc.contributor.author | Cheng, Hazel | - |
dc.contributor.author | Hay, Kazy | - |
dc.contributor.author | Gallinger, Steven | - |
dc.contributor.author | Bapat, Bharati | - |
dc.contributor.author | Mak, Tak W. | - |
dc.date.accessioned | 2020-11-17T14:56:02Z | - |
dc.date.available | 2020-11-17T14:56:02Z | - |
dc.date.issued | 1996 | - |
dc.identifier.citation | Cancer Research, 1996, v. 56, n. 16, p. 3842-3849 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292228 | - |
dc.description.abstract | Hereditary nonpolyposis colorectal cancer is associated with defects in DNA mismatch repair. Here, we characterize tumor susceptibility of the recently described Msh2-deficient mouse model. Within the first year of observation, all homozygous mice succumbed to disease, with lymphomas observed in at least 80% of the cases. The majority (70%) of animals 6 months or older developed intestinal neoplasms associated with APC inactivation. Microsatellite instability was more common in carcinomas than in adenomas, but uncommon in normal tissues. Some animals (7%) developed a variety of skin neoplasms analogous to the Muir-Torre syndrome. Msh2(-/-) mice implicate a direct role for mismatch repair in several neoplasms with striking phenotypic similarities to humans. | - |
dc.language | eng | - |
dc.relation.ispartof | Cancer Research | - |
dc.title | Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.pmid | 8706033 | - |
dc.identifier.scopus | eid_2-s2.0-9444271133 | - |
dc.identifier.volume | 56 | - |
dc.identifier.issue | 16 | - |
dc.identifier.spage | 3842 | - |
dc.identifier.epage | 3849 | - |
dc.identifier.isi | WOS:A1996VB98600042 | - |
dc.identifier.issnl | 0008-5472 | - |