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- Publisher Website: 10.1111/jcmm.12294
- Scopus: eid_2-s2.0-84904987540
- PMID: 24758719
- WOS: WOS:000340413500011
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Article: A novel TLR2-triggered signalling crosstalk synergistically intensifies TNF-mediated IL-6 induction
Title | A novel TLR2-triggered signalling crosstalk synergistically intensifies TNF-mediated IL-6 induction |
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Authors | |
Keywords | TRAF6 Signalling crosstalk Toll-like receptor TRADD Tumour necrosis factor |
Issue Date | 2014 |
Citation | Journal of Cellular and Molecular Medicine, 2014, v. 18, n. 7, p. 1344-1357 How to Cite? |
Abstract | Toll-like receptors (TLR) recognize pathogens and trigger the production of vigorous pro-inflammatory cytokines [such as tumour necrosis factor (TNF)] that induce systemic damages associated with sepsis and chronic inflammation. Cooperation between signals of TLR and TNF receptor has been demonstrated through the participation of TNF receptor 1 (TNFR) adaptors in endotoxin tolerance. Here, we identify a TLR2-mediated synergy, through a MyD88-independent crosstalk, which enhances subsequent TNF-mediated nuclear factor-kappa B activation and interleukin-6 induction. Membrane-associated adaptor MAL conduces the link between TNF receptor-associated factor 6 (TRAF6) and TNFR-associated death domain, leading to a distinctive K63-ubiquitinylated TRAF6 recruitment into TNFR complex. In summary, our results reveal a novel route of TLR signal that synergistically amplifies TNF-mediated responses, indicating an innovative target for inflammation manipulation. |
Persistent Identifier | http://hdl.handle.net/10722/292237 |
ISSN | 2023 Impact Factor: 4.3 2023 SCImago Journal Rankings: 1.207 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chang, Yu Ling | - |
dc.contributor.author | Chen, Tzu Hui | - |
dc.contributor.author | Wu, Yi Hsiu | - |
dc.contributor.author | Chen, Guann An | - |
dc.contributor.author | Weng, Tzu Huei | - |
dc.contributor.author | Tseng, Ping Hui | - |
dc.contributor.author | Hsieh, Shie Liang | - |
dc.contributor.author | Fu, Shu Ling | - |
dc.contributor.author | Lin, Chi Hung | - |
dc.contributor.author | Chen, Chun Jen | - |
dc.contributor.author | Chu, Ching Liang | - |
dc.contributor.author | Chio, Iok In Christine | - |
dc.contributor.author | Mak, Tak Wah | - |
dc.contributor.author | Chen, Nien Jung | - |
dc.date.accessioned | 2020-11-17T14:56:03Z | - |
dc.date.available | 2020-11-17T14:56:03Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Journal of Cellular and Molecular Medicine, 2014, v. 18, n. 7, p. 1344-1357 | - |
dc.identifier.issn | 1582-1838 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292237 | - |
dc.description.abstract | Toll-like receptors (TLR) recognize pathogens and trigger the production of vigorous pro-inflammatory cytokines [such as tumour necrosis factor (TNF)] that induce systemic damages associated with sepsis and chronic inflammation. Cooperation between signals of TLR and TNF receptor has been demonstrated through the participation of TNF receptor 1 (TNFR) adaptors in endotoxin tolerance. Here, we identify a TLR2-mediated synergy, through a MyD88-independent crosstalk, which enhances subsequent TNF-mediated nuclear factor-kappa B activation and interleukin-6 induction. Membrane-associated adaptor MAL conduces the link between TNF receptor-associated factor 6 (TRAF6) and TNFR-associated death domain, leading to a distinctive K63-ubiquitinylated TRAF6 recruitment into TNFR complex. In summary, our results reveal a novel route of TLR signal that synergistically amplifies TNF-mediated responses, indicating an innovative target for inflammation manipulation. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Cellular and Molecular Medicine | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | TRAF6 | - |
dc.subject | Signalling crosstalk | - |
dc.subject | Toll-like receptor | - |
dc.subject | TRADD | - |
dc.subject | Tumour necrosis factor | - |
dc.title | A novel TLR2-triggered signalling crosstalk synergistically intensifies TNF-mediated IL-6 induction | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1111/jcmm.12294 | - |
dc.identifier.pmid | 24758719 | - |
dc.identifier.pmcid | PMC4124019 | - |
dc.identifier.scopus | eid_2-s2.0-84904987540 | - |
dc.identifier.volume | 18 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 1344 | - |
dc.identifier.epage | 1357 | - |
dc.identifier.eissn | 1582-4934 | - |
dc.identifier.isi | WOS:000340413500011 | - |
dc.identifier.issnl | 1582-1838 | - |