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- Publisher Website: 10.1073/pnas.80.16.5037
- Scopus: eid_2-s2.0-0020579601
- PMID: 6576374
- WOS: WOS:A1983RD40300035
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Article: Complete nucleotide sequence of an infectious clone of Friend spleen focus-forming provirus: gp55 is an envelope fusion glycoprotein
Title | Complete nucleotide sequence of an infectious clone of Friend spleen focus-forming provirus: gp55 is an envelope fusion glycoprotein |
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Authors | |
Issue Date | 1983 |
Citation | Proceedings of the National Academy of Sciences of the United States of America, 1983, v. 80, n. 16, p. 5037-5041 How to Cite? |
Abstract | The Friend spleen focus-forming provirus is 6,296 base pairs (bp) in length. Compared to Moloney murine leukemia virus, it has undergone five major deletions, three substitutions, and a number of minor alterations. Otherwise, these viruses are about 90% homologous. A 16-bp palindrome is found in the region thought to be involved in packaging and dimerization of the RNA genome. Premature termination of translation of the gag polyprotein is attributed to a 13-bp deletion in the p12 region. A substitution of xenotropic env sequences was identified in the 5' region of the env gene; 150 nucleotides 3' to this substitution, a deletion of 585 bp removes the site where the normal env precursor protein is cleaved to form gp70 and p15(E), resulting in a fusion protein of M(r) 44,725. Due to these changes, the env product gp55 is expected to have a substantially different conformation on the cell surface compared to either a xenotropic or ecotropic gp70 protein, and may be responsible for the rapid erythroleukemic potential of spleen focus-forming virus. |
Persistent Identifier | http://hdl.handle.net/10722/292274 |
ISSN | 2023 Impact Factor: 9.4 2023 SCImago Journal Rankings: 3.737 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Clark, S. P. | - |
dc.contributor.author | Mak, T. W. | - |
dc.date.accessioned | 2020-11-17T14:56:07Z | - |
dc.date.available | 2020-11-17T14:56:07Z | - |
dc.date.issued | 1983 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the United States of America, 1983, v. 80, n. 16, p. 5037-5041 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292274 | - |
dc.description.abstract | The Friend spleen focus-forming provirus is 6,296 base pairs (bp) in length. Compared to Moloney murine leukemia virus, it has undergone five major deletions, three substitutions, and a number of minor alterations. Otherwise, these viruses are about 90% homologous. A 16-bp palindrome is found in the region thought to be involved in packaging and dimerization of the RNA genome. Premature termination of translation of the gag polyprotein is attributed to a 13-bp deletion in the p12 region. A substitution of xenotropic env sequences was identified in the 5' region of the env gene; 150 nucleotides 3' to this substitution, a deletion of 585 bp removes the site where the normal env precursor protein is cleaved to form gp70 and p15(E), resulting in a fusion protein of M(r) 44,725. Due to these changes, the env product gp55 is expected to have a substantially different conformation on the cell surface compared to either a xenotropic or ecotropic gp70 protein, and may be responsible for the rapid erythroleukemic potential of spleen focus-forming virus. | - |
dc.language | eng | - |
dc.relation.ispartof | Proceedings of the National Academy of Sciences of the United States of America | - |
dc.title | Complete nucleotide sequence of an infectious clone of Friend spleen focus-forming provirus: gp55 is an envelope fusion glycoprotein | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1073/pnas.80.16.5037 | - |
dc.identifier.pmid | 6576374 | - |
dc.identifier.pmcid | PMC384183 | - |
dc.identifier.scopus | eid_2-s2.0-0020579601 | - |
dc.identifier.volume | 80 | - |
dc.identifier.issue | 16 | - |
dc.identifier.spage | 5037 | - |
dc.identifier.epage | 5041 | - |
dc.identifier.isi | WOS:A1983RD40300035 | - |
dc.identifier.issnl | 0027-8424 | - |