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Article: Developmentally regulated rearrangement and expression of genes encoding the T cell receptor-T3 complex

TitleDevelopmentally regulated rearrangement and expression of genes encoding the T cell receptor-T3 complex
Authors
Issue Date1986
Citation
Cell, 1986, v. 46, n. 1, p. 75-87 How to Cite?
AbstractHuman leukemic cells corresponding to the earliest identifiable stages of intrathymic T cell differentiation lack cell surface expression of the T cell receptor(TCRα/β)-T3 complex but transcribe TCRβ mRNA from either germ-line configuration ( 1 13) or partially (DJ) or fully (VDJ) rearranged ( 12 13) genes. These cells do not produce TCRα mRNA, but do contain T3δ and T3ε{lunate} mRNA and accumulate T3 polypeptides, primarily in the perinuclear envelope. Equivalent normal T cells isolated from thymus have a predominantly germ-line configuration of TCRβ but contain intracellular T3 proteins. T3 gene expression is therefore a very early event in T cell differentiation. TCRα chain production appears to be the limiting maturation-linked event in the transport, assembly, and cell surface membrane insertion of the TCRα β-T3 complex. © 1986.
Persistent Identifierhttp://hdl.handle.net/10722/292312
ISSN
2023 Impact Factor: 45.5
2023 SCImago Journal Rankings: 24.342
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFurley, A. J.-
dc.contributor.authorMizutani, S.-
dc.contributor.authorWeilbaecher, K.-
dc.contributor.authorDhaliwal, H. S.-
dc.contributor.authorFord, A. M.-
dc.contributor.authorChan, L. C.-
dc.contributor.authorMolgaard, H. V.-
dc.contributor.authorToyonaga, B.-
dc.contributor.authorMak, T.-
dc.contributor.authorvan den Elsen, P.-
dc.contributor.authorGold, D.-
dc.contributor.authorTerhorst, C.-
dc.contributor.authorGreaves, M. F.-
dc.date.accessioned2020-11-17T14:56:12Z-
dc.date.available2020-11-17T14:56:12Z-
dc.date.issued1986-
dc.identifier.citationCell, 1986, v. 46, n. 1, p. 75-87-
dc.identifier.issn0092-8674-
dc.identifier.urihttp://hdl.handle.net/10722/292312-
dc.description.abstractHuman leukemic cells corresponding to the earliest identifiable stages of intrathymic T cell differentiation lack cell surface expression of the T cell receptor(TCRα/β)-T3 complex but transcribe TCRβ mRNA from either germ-line configuration ( 1 13) or partially (DJ) or fully (VDJ) rearranged ( 12 13) genes. These cells do not produce TCRα mRNA, but do contain T3δ and T3ε{lunate} mRNA and accumulate T3 polypeptides, primarily in the perinuclear envelope. Equivalent normal T cells isolated from thymus have a predominantly germ-line configuration of TCRβ but contain intracellular T3 proteins. T3 gene expression is therefore a very early event in T cell differentiation. TCRα chain production appears to be the limiting maturation-linked event in the transport, assembly, and cell surface membrane insertion of the TCRα β-T3 complex. © 1986.-
dc.languageeng-
dc.relation.ispartofCell-
dc.titleDevelopmentally regulated rearrangement and expression of genes encoding the T cell receptor-T3 complex-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/0092-8674(86)90861-5-
dc.identifier.pmid3087626-
dc.identifier.scopuseid_2-s2.0-0022922521-
dc.identifier.volume46-
dc.identifier.issue1-
dc.identifier.spage75-
dc.identifier.epage87-
dc.identifier.isiWOS:A1986D125500009-
dc.identifier.issnl0092-8674-

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