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Article: Molecular analysis of the antigen receptor of virus‐specific cytotoxic T cells and identification of a new Vα family

TitleMolecular analysis of the antigen receptor of virus‐specific cytotoxic T cells and identification of a new V<inf>α</inf> family
Authors
Pircher, HanspeterMichalopoulos, E. EffieIwamoto, AichikiOhashi, Pamela S.Baenziger, JurgHengartner, HansZinkernagel, Rolf M.Mak, Tak W.
Issue Date1987
Citation
European Journal of Immunology, 1987, v. 17, n. 12, p. 1843-1846 How to Cite?
DOI: http://dx.doi.org/10.1002/eji.1830171226
AbstractWe have determined the primary structure of the α/β‐antigen receptor of a lymphocytic choriomeningitis virus (LCMV)‐specific cytotoxic T cell clone (P14). The β chain of the T cell receptor is composed of Vβ8.1, Dβ and Jβ2.4 gene segments while the α chain uses a member of the Vα2 family and Jα TA31. Southern blot analysis of a panel of six other independent LCMV‐specific cytotoxic T cell clones did not reveal any preferential usage of the Vα2 or Vβ8 gene families in the cytotoxic LCMV response. Additionally, we have isolated and sequenced cDNA clones derived from the non‐functionally rearranged α allele of P14. This transcript is composed of a unique Vα gene segment which belongs to a new Vα gene family. Copyright © 1987 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
Persistent Identifierhttp://hdl.handle.net/10722/292327
ISSN
0014-2980
2021 Impact Factor: 6.688
2020 SCImago Journal Rankings: 2.272
ISI Accession Number ID
WOS:A1987L902900026

 

DC FieldValueLanguage
dc.contributor.authorPircher, Hanspeter-
dc.contributor.authorMichalopoulos, E. Effie-
dc.contributor.authorIwamoto, Aichiki-
dc.contributor.authorOhashi, Pamela S.-
dc.contributor.authorBaenziger, Jurg-
dc.contributor.authorHengartner, Hans-
dc.contributor.authorZinkernagel, Rolf M.-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:56:14Z-
dc.date.available2020-11-17T14:56:14Z-
dc.date.issued1987-
dc.identifier.citationEuropean Journal of Immunology, 1987, v. 17, n. 12, p. 1843-1846-
dc.identifier.issn0014-2980-
dc.identifier.urihttp://hdl.handle.net/10722/292327-
dc.description.abstractWe have determined the primary structure of the α/β‐antigen receptor of a lymphocytic choriomeningitis virus (LCMV)‐specific cytotoxic T cell clone (P14). The β chain of the T cell receptor is composed of Vβ8.1, Dβ and Jβ2.4 gene segments while the α chain uses a member of the Vα2 family and Jα TA31. Southern blot analysis of a panel of six other independent LCMV‐specific cytotoxic T cell clones did not reveal any preferential usage of the Vα2 or Vβ8 gene families in the cytotoxic LCMV response. Additionally, we have isolated and sequenced cDNA clones derived from the non‐functionally rearranged α allele of P14. This transcript is composed of a unique Vα gene segment which belongs to a new Vα gene family. Copyright © 1987 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim-
dc.languageeng-
dc.relation.ispartofEuropean Journal of Immunology-
dc.titleMolecular analysis of the antigen receptor of virus‐specific cytotoxic T cells and identification of a new V<inf>α</inf> family-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/eji.1830171226-
dc.identifier.pmid2961577-
dc.identifier.scopuseid_2-s2.0-0023632164-
dc.identifier.volume17-
dc.identifier.issue12-
dc.identifier.spage1843-
dc.identifier.epage1846-
dc.identifier.eissn1521-4141-
dc.identifier.isiWOS:A1987L902900026-
dc.identifier.issnl0014-2980-

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