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Article: T cell receptor δ gene rearrangements in acute lymphoblastic leukemia

TitleT cell receptor δ gene rearrangements in acute lymphoblastic leukemia
Authors
Issue Date1988
Citation
Journal of Clinical Investigation, 1988, v. 82, n. 6, p. 1974-1982 How to Cite?
AbstractUsing a newly isolated cDNA clone encoding the TCR-δ gene and genomic probes, we have analyzed T cell receptor (TCR) δ gene rearrangement in 19 patients with T cell acute lymphoblastic leukemia (T-ALL) and 29 patients with B-precursor ALL. Five out of seven CD3- T-ALL and 4 of 12 CD3+ T-ALL showed bi-allelic rearrangements of the TCR-δ gene. In three CD3+ patients, a single allelic TCR-δ gene rearrangement was observed with rearrangement of the TCR-α gene on the other allele. In five CD3+ patients with bi-allelic rearrangements of the TCR-α gene, the TCR-δ gene locus was deleted. Transcription of the TCR-δ gene was also analyzed in six T-ALL. Five patients expressed TCR-δ transcripts. Only one T-ALL, presumably derived from the most immature T lineage cells, did not have TCR-δ transcripts, but expressed TCR-γ and 1.0-kb truncated TCR-β transcripts. In B-precursor ALL, 20 patients (69%) showed rearrangements of the TCR-δ gene. The frequency of TCR-δ gene rearrangement was higher than TCR-α (59%), γ (52%), or β (31%) genes. These findings suggest that TCR-α gene rearrangements may take place after rearrangements of the TCR-δ gene with concomitant deletion of rearranged TCR-δ genes in T cell differentiation. Among leukemic cells of B lineage, the TCR-δ gene is the earliest rearranging TCR gene, followed by TCR-γ and β gene rearrangements.
Persistent Identifierhttp://hdl.handle.net/10722/292345
ISSN
2023 Impact Factor: 13.3
2023 SCImago Journal Rankings: 4.833
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHara, J.-
dc.contributor.authorBenedict, S. H.-
dc.contributor.authorChampagne, E.-
dc.contributor.authorTakihara, Y.-
dc.contributor.authorMak, T. W.-
dc.contributor.authorMinden, M.-
dc.contributor.authorGelfand, E. W.-
dc.date.accessioned2020-11-17T14:56:16Z-
dc.date.available2020-11-17T14:56:16Z-
dc.date.issued1988-
dc.identifier.citationJournal of Clinical Investigation, 1988, v. 82, n. 6, p. 1974-1982-
dc.identifier.issn0021-9738-
dc.identifier.urihttp://hdl.handle.net/10722/292345-
dc.description.abstractUsing a newly isolated cDNA clone encoding the TCR-δ gene and genomic probes, we have analyzed T cell receptor (TCR) δ gene rearrangement in 19 patients with T cell acute lymphoblastic leukemia (T-ALL) and 29 patients with B-precursor ALL. Five out of seven CD3- T-ALL and 4 of 12 CD3+ T-ALL showed bi-allelic rearrangements of the TCR-δ gene. In three CD3+ patients, a single allelic TCR-δ gene rearrangement was observed with rearrangement of the TCR-α gene on the other allele. In five CD3+ patients with bi-allelic rearrangements of the TCR-α gene, the TCR-δ gene locus was deleted. Transcription of the TCR-δ gene was also analyzed in six T-ALL. Five patients expressed TCR-δ transcripts. Only one T-ALL, presumably derived from the most immature T lineage cells, did not have TCR-δ transcripts, but expressed TCR-γ and 1.0-kb truncated TCR-β transcripts. In B-precursor ALL, 20 patients (69%) showed rearrangements of the TCR-δ gene. The frequency of TCR-δ gene rearrangement was higher than TCR-α (59%), γ (52%), or β (31%) genes. These findings suggest that TCR-α gene rearrangements may take place after rearrangements of the TCR-δ gene with concomitant deletion of rearranged TCR-δ genes in T cell differentiation. Among leukemic cells of B lineage, the TCR-δ gene is the earliest rearranging TCR gene, followed by TCR-γ and β gene rearrangements.-
dc.languageeng-
dc.relation.ispartofJournal of Clinical Investigation-
dc.titleT cell receptor δ gene rearrangements in acute lymphoblastic leukemia-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1172/JCI113817-
dc.identifier.pmid2848865-
dc.identifier.pmcidPMC442779-
dc.identifier.scopuseid_2-s2.0-0024239624-
dc.identifier.volume82-
dc.identifier.issue6-
dc.identifier.spage1974-
dc.identifier.epage1982-
dc.identifier.isiWOS:A1988R283600022-
dc.identifier.issnl0021-9738-

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