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Article: Organization and orientation of a human T cell receptor δ chain V gene segment that suggests an inversion mechanism is utilized in its rearrangement

TitleOrganization and orientation of a human T cell receptor δ chain V gene segment that suggests an inversion mechanism is utilized in its rearrangement
Authors
Takihara, YoshihiroChampagne, EricCiccone, ErmannoMoretta, LorenzoMinden, MarkMak, Tak W.
Issue Date1989
Citation
European Journal of Immunology, 1989, v. 19, n. 3, p. 571-574 How to Cite?
DOI: http://dx.doi.org/10.1002/eji.1830190327
AbstractA human T cell receptor (TcR) δ chain variable region segment, Vδ3, has been mapped 2 kilobases 3′ to the constant (Cδ) gene. The Vδ3 gene segment is in an inverted transcriptional orientation to the diversity regions (Dδ), joining regions (Jδ) and Cδ gene segments. Analyses of TcR δ cDNA clone, KT041, showed that Vδ3 is linked to Dδ1, Dδ2, Jδ3 and Cδ and that this message encodes a potentially functional TcR δ chain. These findings indicate that a functional TcR δ gene can be constructed through a chromosomal inversion, suggesting that in human, chromosomal inversion is one of the important rearrangement mechanisms. Copyright © 1989 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
Persistent Identifierhttp://hdl.handle.net/10722/292361
ISSN
0014-2980
2023 Impact Factor: 4.5
2023 SCImago Journal Rankings: 1.627
ISI Accession Number ID
WOS:A1989U629900026

 

DC FieldValueLanguage
dc.contributor.authorTakihara, Yoshihiro-
dc.contributor.authorChampagne, Eric-
dc.contributor.authorCiccone, Ermanno-
dc.contributor.authorMoretta, Lorenzo-
dc.contributor.authorMinden, Mark-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:56:18Z-
dc.date.available2020-11-17T14:56:18Z-
dc.date.issued1989-
dc.identifier.citationEuropean Journal of Immunology, 1989, v. 19, n. 3, p. 571-574-
dc.identifier.issn0014-2980-
dc.identifier.urihttp://hdl.handle.net/10722/292361-
dc.description.abstractA human T cell receptor (TcR) δ chain variable region segment, Vδ3, has been mapped 2 kilobases 3′ to the constant (Cδ) gene. The Vδ3 gene segment is in an inverted transcriptional orientation to the diversity regions (Dδ), joining regions (Jδ) and Cδ gene segments. Analyses of TcR δ cDNA clone, KT041, showed that Vδ3 is linked to Dδ1, Dδ2, Jδ3 and Cδ and that this message encodes a potentially functional TcR δ chain. These findings indicate that a functional TcR δ gene can be constructed through a chromosomal inversion, suggesting that in human, chromosomal inversion is one of the important rearrangement mechanisms. Copyright © 1989 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim-
dc.languageeng-
dc.relation.ispartofEuropean Journal of Immunology-
dc.titleOrganization and orientation of a human T cell receptor δ chain V gene segment that suggests an inversion mechanism is utilized in its rearrangement-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/eji.1830190327-
dc.identifier.pmid2523312-
dc.identifier.scopuseid_2-s2.0-0024593356-
dc.identifier.volume19-
dc.identifier.issue3-
dc.identifier.spage571-
dc.identifier.epage574-
dc.identifier.eissn1521-4141-
dc.identifier.isiWOS:A1989U629900026-
dc.identifier.issnl0014-2980-

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