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- Publisher Website: 10.1182/blood.V73.6.1672.1672
- Scopus: eid_2-s2.0-0024598152
- PMID: 2523742
- WOS: WOS:A1989U433100039
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Article: The T-cell receptor delta chain locus is disrupted in the T-ALL associated t(11;14) (p13;q11) translocation
| Title | The T-cell receptor delta chain locus is disrupted in the T-ALL associated t(11;14) (p13;q11) translocation |
|---|---|
| Authors | |
| Issue Date | 1989 |
| Citation | Blood, 1989, v. 73, n. 6, p. 1672-1676 How to Cite? |
| Abstract | Two T-ALL patients carrying a t(11;14) (p13;q11) translocation were analyzed. Southern blotting experiments demonstrated that both patients had rearranged their Jδ genes and that the translocation involved the δ locus in both cases. In one patient, cloning, restriction mapping, and sequencing showed that the translocation occurred on a Dδ1-Dδ2-Jδ2 rearranged gene. In addition, the rearrangement on chromosome 11 occurred in both patients within a segment of ≤ 2 kb showing the presence in this region of a point of recurrent recombination. |
| Persistent Identifier | http://hdl.handle.net/10722/292362 |
| ISSN | 2023 Impact Factor: 21.0 2023 SCImago Journal Rankings: 5.272 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Champagne, E. | - |
| dc.contributor.author | Takihara, Y. | - |
| dc.contributor.author | Sagman, U. | - |
| dc.contributor.author | De Sousa, J. | - |
| dc.contributor.author | Burrow, S. | - |
| dc.contributor.author | Lewis, W. H. | - |
| dc.contributor.author | Mak, T. W. | - |
| dc.contributor.author | Minden, M. D. | - |
| dc.date.accessioned | 2020-11-17T14:56:18Z | - |
| dc.date.available | 2020-11-17T14:56:18Z | - |
| dc.date.issued | 1989 | - |
| dc.identifier.citation | Blood, 1989, v. 73, n. 6, p. 1672-1676 | - |
| dc.identifier.issn | 0006-4971 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/292362 | - |
| dc.description.abstract | Two T-ALL patients carrying a t(11;14) (p13;q11) translocation were analyzed. Southern blotting experiments demonstrated that both patients had rearranged their Jδ genes and that the translocation involved the δ locus in both cases. In one patient, cloning, restriction mapping, and sequencing showed that the translocation occurred on a Dδ1-Dδ2-Jδ2 rearranged gene. In addition, the rearrangement on chromosome 11 occurred in both patients within a segment of ≤ 2 kb showing the presence in this region of a point of recurrent recombination. | - |
| dc.language | eng | - |
| dc.relation.ispartof | Blood | - |
| dc.title | The T-cell receptor delta chain locus is disrupted in the T-ALL associated t(11;14) (p13;q11) translocation | - |
| dc.type | Article | - |
| dc.description.nature | link_to_OA_fulltext | - |
| dc.identifier.doi | 10.1182/blood.V73.6.1672.1672 | - |
| dc.identifier.pmid | 2523742 | - |
| dc.identifier.scopus | eid_2-s2.0-0024598152 | - |
| dc.identifier.volume | 73 | - |
| dc.identifier.issue | 6 | - |
| dc.identifier.spage | 1672 | - |
| dc.identifier.epage | 1676 | - |
| dc.identifier.isi | WOS:A1989U433100039 | - |
| dc.identifier.issnl | 0006-4971 | - |