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Article: T cell receptor and immunoglobulin genes in hematologic malignancies

TitleT cell receptor and immunoglobulin genes in hematologic malignancies
Authors
Reis, Marciano D.Griesser, HenrikMak, Tak W.
KeywordsGene rearrangements
Leukemia
Lymphoma
Issue Date1990
Citation
Tumor Biology, 1990, v. 11, p. 59-77 How to Cite?
DOI: http://dx.doi.org/10.1159/000217677
AbstractIn this review, we discuss the structure, organization and activation of the immunoglobulin (Ig) and T cell receptor (TCR) genes and the use of DNA probes derived from these genes as tools to determine clonality and cell lineage in hemopoietic malignancies. We also examined briefly the participation of immunoglobulin and TCR genes in chromosomal aberrations present in many lymphoproliferative disorders, often involving protooncogenes and potentially of tumorigenic consequences. © 1990 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/292368
ISSN
1010-4283
2016 Impact Factor: 3.650
2023 SCImago Journal Rankings: 0.576
ISI Accession Number ID
WOS:A1990EL50200005

 

DC FieldValueLanguage
dc.contributor.authorReis, Marciano D.-
dc.contributor.authorGriesser, Henrik-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:56:19Z-
dc.date.available2020-11-17T14:56:19Z-
dc.date.issued1990-
dc.identifier.citationTumor Biology, 1990, v. 11, p. 59-77-
dc.identifier.issn1010-4283-
dc.identifier.urihttp://hdl.handle.net/10722/292368-
dc.description.abstractIn this review, we discuss the structure, organization and activation of the immunoglobulin (Ig) and T cell receptor (TCR) genes and the use of DNA probes derived from these genes as tools to determine clonality and cell lineage in hemopoietic malignancies. We also examined briefly the participation of immunoglobulin and TCR genes in chromosomal aberrations present in many lymphoproliferative disorders, often involving protooncogenes and potentially of tumorigenic consequences. © 1990 S. Karger AG, Basel.-
dc.languageeng-
dc.relation.ispartofTumor Biology-
dc.subjectGene rearrangements-
dc.subjectLeukemia-
dc.subjectLymphoma-
dc.titleT cell receptor and immunoglobulin genes in hematologic malignancies-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000217677-
dc.identifier.pmid2247756-
dc.identifier.scopuseid_2-s2.0-0025132908-
dc.identifier.volume11-
dc.identifier.spage59-
dc.identifier.epage77-
dc.identifier.eissn1423-0380-
dc.identifier.isiWOS:A1990EL50200005-
dc.identifier.issnl1010-4283-

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