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Article: Characterization of a Monoclonal Antibody Directed Against the Phosphotyrosine Kinase p56lck, in Human T Cells

TitleCharacterization of a Monoclonal Antibody Directed Against the Phosphotyrosine Kinase p56<sup>lck</sup>, in Human T Cells
Authors
ANSOTEGUI, I. J.CHOW, S. C.JEDDI‐TEHRANI, M.MELOCHE, S.PAWSON, A.SEKALY, R. ‐PMAKI, T. W.WIGZELL, H.
Issue Date1991
Citation
Scandinavian Journal of Immunology, 1991, v. 33, n. 4, p. 375-380 How to Cite?
DOI: http://dx.doi.org/10.1111/j.1365-3083.1991.tb01784.x
AbstractA monoclonal antibody (anti‐p56lck) was generated against a fusion protein containing the residues 145–509 of the human p56lck, a lymphoeyte‐specific membrane‐associated protein tyrosine kinase. The involvement of this enzyme in T‐cell transmembrane signalling seems to be an early and crucial event during T‐cell receptor‐mediated activation. We have produced a monoclonal antibody which recognizes p56lck in free form and when associated with CD4. H functions in western blot analysis and is capable of selectively blocking auto‐phosphorylation of this kinase. This monoclonal antibody should be useful for investigating the role of p56lck in T‐cell activation. Copyright © 1991, Wiley Blackwell. All rights reserved
Persistent Identifierhttp://hdl.handle.net/10722/292379
ISSN
0300-9475
2023 Impact Factor: 4.1
2023 SCImago Journal Rankings: 0.946
ISI Accession Number ID
WOS:A1991FD94300005

 

DC FieldValueLanguage
dc.contributor.authorANSOTEGUI, I. J.-
dc.contributor.authorCHOW, S. C.-
dc.contributor.authorJEDDI‐TEHRANI, M.-
dc.contributor.authorMELOCHE, S.-
dc.contributor.authorPAWSON, A.-
dc.contributor.authorSEKALY, R. ‐P-
dc.contributor.authorMAKI, T. W.-
dc.contributor.authorWIGZELL, H.-
dc.date.accessioned2020-11-17T14:56:22Z-
dc.date.available2020-11-17T14:56:22Z-
dc.date.issued1991-
dc.identifier.citationScandinavian Journal of Immunology, 1991, v. 33, n. 4, p. 375-380-
dc.identifier.issn0300-9475-
dc.identifier.urihttp://hdl.handle.net/10722/292379-
dc.description.abstractA monoclonal antibody (anti‐p56lck) was generated against a fusion protein containing the residues 145–509 of the human p56lck, a lymphoeyte‐specific membrane‐associated protein tyrosine kinase. The involvement of this enzyme in T‐cell transmembrane signalling seems to be an early and crucial event during T‐cell receptor‐mediated activation. We have produced a monoclonal antibody which recognizes p56lck in free form and when associated with CD4. H functions in western blot analysis and is capable of selectively blocking auto‐phosphorylation of this kinase. This monoclonal antibody should be useful for investigating the role of p56lck in T‐cell activation. Copyright © 1991, Wiley Blackwell. All rights reserved-
dc.languageeng-
dc.relation.ispartofScandinavian Journal of Immunology-
dc.titleCharacterization of a Monoclonal Antibody Directed Against the Phosphotyrosine Kinase p56<sup>lck</sup>, in Human T Cells-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1365-3083.1991.tb01784.x-
dc.identifier.pmid2017663-
dc.identifier.scopuseid_2-s2.0-0025806486-
dc.identifier.volume33-
dc.identifier.issue4-
dc.identifier.spage375-
dc.identifier.epage380-
dc.identifier.eissn1365-3083-
dc.identifier.isiWOS:A1991FD94300005-
dc.identifier.issnl0300-9475-

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