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Article: CD4, CD8 and tyrosine kinases in thymic selection

TitleCD4, CD8 and tyrosine kinases in thymic selection
Authors
Wallace, Valerie A.Penninger, JosefMak, Tak W.
Issue Date1993
Citation
Current Opinion in Immunology, 1993, v. 5, n. 2, p. 235-240 How to Cite?
DOI: http://dx.doi.org/10.1016/0952-7915(93)90010-P
AbstractAnalysis of T-cell development in transgenic and gene-deficient mice suggests that the co-receptor function of CD8 is essential for positive selection. Recent data also demonstrate that the requirement for CD4 and CD8 in negative selection of T cells is not absolute and may be regulated by T-cell receptor affinity for the deleting ligand, an interpretation consistent with the affinity model of thymic selection. In addition to its association with CD4 and CD8, it appears that p56lck is also important during the early stages of thymic development. © 1993.
Persistent Identifierhttp://hdl.handle.net/10722/292403
ISSN
0952-7915
2023 Impact Factor: 6.6
2023 SCImago Journal Rankings: 2.841
ISI Accession Number ID
WOS:A1993KY90900010

 

DC FieldValueLanguage
dc.contributor.authorWallace, Valerie A.-
dc.contributor.authorPenninger, Josef-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:56:25Z-
dc.date.available2020-11-17T14:56:25Z-
dc.date.issued1993-
dc.identifier.citationCurrent Opinion in Immunology, 1993, v. 5, n. 2, p. 235-240-
dc.identifier.issn0952-7915-
dc.identifier.urihttp://hdl.handle.net/10722/292403-
dc.description.abstractAnalysis of T-cell development in transgenic and gene-deficient mice suggests that the co-receptor function of CD8 is essential for positive selection. Recent data also demonstrate that the requirement for CD4 and CD8 in negative selection of T cells is not absolute and may be regulated by T-cell receptor affinity for the deleting ligand, an interpretation consistent with the affinity model of thymic selection. In addition to its association with CD4 and CD8, it appears that p56lck is also important during the early stages of thymic development. © 1993.-
dc.languageeng-
dc.relation.ispartofCurrent Opinion in Immunology-
dc.titleCD4, CD8 and tyrosine kinases in thymic selection-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/0952-7915(93)90010-P-
dc.identifier.pmid8507400-
dc.identifier.scopuseid_2-s2.0-0027156322-
dc.identifier.volume5-
dc.identifier.issue2-
dc.identifier.spage235-
dc.identifier.epage240-
dc.identifier.isiWOS:A1993KY90900010-
dc.identifier.issnl0952-7915-

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