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Article: The induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules [corrected]

TitleThe induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules [corrected]
Authors
Issue Date1993
Citation
Journal of Experimental Medicine, 1993, v. 178, n. 5, p. 1837-1842 How to Cite?
AbstractExperimental induction of most autoimmune diseases appears to depend on the activation of CD4+ T helper cells, while CD8+ lymphocytes may have a role in disease progression. To study the role of CD4+ and CD8+ T cell subsets in T cell-dependent autoimmunity, mice lacking CD4 or CD8 molecules after gene targeting were injected with cardiac myosin to induce organ specific autoimmune myocarditis. Mice homozygous for the CD8 mutation (CD8−/−) developed significantly more severe disease as compared to CD4+/−CD8+/− controls. Surprisingly, CD4−/− mice developed autoimmune myocarditis with infiltration of TCRαβ+CD4−CD8− T cells in the heart tissue and appearance of autoantibodies. These data demonstrate that the lack of CD4+ or CD8+ T ceils has no significant influence on the initiation of autoimmune myocarditis. CD4+ and CD8+ cells regulate disease severity and these results may explain the occurrence of autoimmunity in CD4 immunodeficiencies. © 1993, Rockefeller University Press., All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/292419
ISSN
2023 Impact Factor: 12.6
2023 SCImago Journal Rankings: 6.838
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPenninger, Josef M.-
dc.contributor.authorNeu, Nikolaus-
dc.contributor.authorTimms, Emma-
dc.contributor.authorWallace, Valerie A.-
dc.contributor.authorKoh, Dow Rhoon-
dc.contributor.authorKishihara, Kenji-
dc.contributor.authorPummerer, Christian-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:56:27Z-
dc.date.available2020-11-17T14:56:27Z-
dc.date.issued1993-
dc.identifier.citationJournal of Experimental Medicine, 1993, v. 178, n. 5, p. 1837-1842-
dc.identifier.issn0022-1007-
dc.identifier.urihttp://hdl.handle.net/10722/292419-
dc.description.abstractExperimental induction of most autoimmune diseases appears to depend on the activation of CD4+ T helper cells, while CD8+ lymphocytes may have a role in disease progression. To study the role of CD4+ and CD8+ T cell subsets in T cell-dependent autoimmunity, mice lacking CD4 or CD8 molecules after gene targeting were injected with cardiac myosin to induce organ specific autoimmune myocarditis. Mice homozygous for the CD8 mutation (CD8−/−) developed significantly more severe disease as compared to CD4+/−CD8+/− controls. Surprisingly, CD4−/− mice developed autoimmune myocarditis with infiltration of TCRαβ+CD4−CD8− T cells in the heart tissue and appearance of autoantibodies. These data demonstrate that the lack of CD4+ or CD8+ T ceils has no significant influence on the initiation of autoimmune myocarditis. CD4+ and CD8+ cells regulate disease severity and these results may explain the occurrence of autoimmunity in CD4 immunodeficiencies. © 1993, Rockefeller University Press., All rights reserved.-
dc.languageeng-
dc.relation.ispartofJournal of Experimental Medicine-
dc.titleThe induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules [corrected]-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1084/jem.178.5.1837-
dc.identifier.pmid8228830-
dc.identifier.pmcidPMC2191227-
dc.identifier.scopuseid_2-s2.0-0027451443-
dc.identifier.volume178-
dc.identifier.issue5-
dc.identifier.spage1837-
dc.identifier.epage1842-
dc.identifier.eissn1540-9538-
dc.identifier.isiWOS:A1993MD95300043-
dc.identifier.issnl0022-1007-

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