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Article: Thymic Selection of Cytotoxic T Cells Independent of CD8α-Lck Association

TitleThymic Selection of Cytotoxic T Cells Independent of CD8α-Lck Association
Authors
Chan, Iris T.Limmer, AndreasLouie, Marjorie C.Bullock, Eric D.Fung-Leung, Wai PingMak, Tak W.Loh, Dennis Y.
Issue Date1993
Citation
Science, 1993, v. 261, n. 5128, p. 1581-1584 How to Cite?
DOI: http://dx.doi.org/10.1126/science.8372352
AbstractThe CD8α cytoplasmic domain associates with p56lck, a nonreceptor protein-tyrosine kinase. The biological relevance of CD8α-Lck association in T cell development was tested with transgenic mice generated to express a CD8α molecule with two amino acid substitutions in its cytoplasmic domain, which abolishes the association of CD8α with Lck. The CD8α mutant was analyzed in a CD8-/- background and in the context of the transgenic 2C T cell receptor. The development and function of CD8+ T cells in these mice were apparently normal. Thus, CD8α-Lck association is not necessary for positive selection, negative selection, or CD8-dependent cytotoxic function.
Persistent Identifierhttp://hdl.handle.net/10722/292424
ISSN
0036-8075
2023 Impact Factor: 44.7
2023 SCImago Journal Rankings: 11.902
ISI Accession Number ID
WOS:A1993LX47400031

 

DC FieldValueLanguage
dc.contributor.authorChan, Iris T.-
dc.contributor.authorLimmer, Andreas-
dc.contributor.authorLouie, Marjorie C.-
dc.contributor.authorBullock, Eric D.-
dc.contributor.authorFung-Leung, Wai Ping-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorLoh, Dennis Y.-
dc.date.accessioned2020-11-17T14:56:27Z-
dc.date.available2020-11-17T14:56:27Z-
dc.date.issued1993-
dc.identifier.citationScience, 1993, v. 261, n. 5128, p. 1581-1584-
dc.identifier.issn0036-8075-
dc.identifier.urihttp://hdl.handle.net/10722/292424-
dc.description.abstractThe CD8α cytoplasmic domain associates with p56lck, a nonreceptor protein-tyrosine kinase. The biological relevance of CD8α-Lck association in T cell development was tested with transgenic mice generated to express a CD8α molecule with two amino acid substitutions in its cytoplasmic domain, which abolishes the association of CD8α with Lck. The CD8α mutant was analyzed in a CD8-/- background and in the context of the transgenic 2C T cell receptor. The development and function of CD8+ T cells in these mice were apparently normal. Thus, CD8α-Lck association is not necessary for positive selection, negative selection, or CD8-dependent cytotoxic function.-
dc.languageeng-
dc.relation.ispartofScience-
dc.titleThymic Selection of Cytotoxic T Cells Independent of CD8α-Lck Association-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1126/science.8372352-
dc.identifier.pmid8372352-
dc.identifier.scopuseid_2-s2.0-0027501143-
dc.identifier.volume261-
dc.identifier.issue5128-
dc.identifier.spage1581-
dc.identifier.epage1584-
dc.identifier.isiWOS:A1993LX47400031-
dc.identifier.issnl0036-8075-

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