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Article: CD4 negative mice as a model for immunodeficiency.

TitleCD4 negative mice as a model for immunodeficiency.
Authors
Rahemtulla, A.Shahinian, A.Kundig, T.Zinkernagel, R.Mak, T. W.
Issue Date1993
Citation
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 1993, v. 342, n. 1299, p. 57-58 How to Cite?
DOI: http://dx.doi.org/10.1098/rstb.1993.0135
AbstractCD4 is a co-receptor required for T cell helper functions. A mouse strain without CD4 expression has been generated. These animals, surprisingly have a normal CTL response and reduced, but not absent, humoral responses. A new population of MHC class II restricted CD4-CD8-TcR alpha beta+ T cells has emerged which possess helper function potential. These findings have important implications on disease situations where CD4 cells are decreased or absent.
Persistent Identifierhttp://hdl.handle.net/10722/292428
ISSN
0962-8436
2023 Impact Factor: 5.4
2023 SCImago Journal Rankings: 2.035
ISI Accession Number ID
WOS:A1993MH27700008

 

DC FieldValueLanguage
dc.contributor.authorRahemtulla, A.-
dc.contributor.authorShahinian, A.-
dc.contributor.authorKundig, T.-
dc.contributor.authorZinkernagel, R.-
dc.contributor.authorMak, T. W.-
dc.date.accessioned2020-11-17T14:56:28Z-
dc.date.available2020-11-17T14:56:28Z-
dc.date.issued1993-
dc.identifier.citationPhilosophical transactions of the Royal Society of London. Series B, Biological sciences, 1993, v. 342, n. 1299, p. 57-58-
dc.identifier.issn0962-8436-
dc.identifier.urihttp://hdl.handle.net/10722/292428-
dc.description.abstractCD4 is a co-receptor required for T cell helper functions. A mouse strain without CD4 expression has been generated. These animals, surprisingly have a normal CTL response and reduced, but not absent, humoral responses. A new population of MHC class II restricted CD4-CD8-TcR alpha beta+ T cells has emerged which possess helper function potential. These findings have important implications on disease situations where CD4 cells are decreased or absent.-
dc.languageeng-
dc.relation.ispartofPhilosophical transactions of the Royal Society of London. Series B, Biological sciences-
dc.titleCD4 negative mice as a model for immunodeficiency.-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1098/rstb.1993.0135-
dc.identifier.pmid7904347-
dc.identifier.scopuseid_2-s2.0-0027925927-
dc.identifier.volume342-
dc.identifier.issue1299-
dc.identifier.spage57-
dc.identifier.epage58-
dc.identifier.isiWOS:A1993MH27700008-
dc.identifier.issnl0962-8436-

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