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- Publisher Website: 10.1126/science.7510419
- Scopus: eid_2-s2.0-0028348307
- PMID: 7510419
- WOS: WOS:A1994NB67300032
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Article: Requirement for transcription factor IRF-1 in NO synthase induction in macrophages
Title | Requirement for transcription factor IRF-1 in NO synthase induction in macrophages |
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Authors | |
Issue Date | 1994 |
Citation | Science, 1994, v. 263, n. 5153, p. 1612-1615 How to Cite? |
Abstract | Production of nitric oxide (NO) by macrophages is important for the killing of intracellular infectious agents. Interferon (IFN)-γ and lipopolysaccharide stimulate NO production by transcriptionally up-regulating the inducible NO synthase (iNOS). Macrophages from mice with a targeted disruption of the IFN regulatory factor-1 (IRF-1) gene (IRF-I-/- mice) produced little or no NO and synthesized barely detectable iNOS messenger RNA in response to stimulation. Two adjacent IRF-1 response elements were identified in the iNOS promoter. Infection with Mycobacterium bovis (BCG) was more severe in IRF-1-/- mice than in wild-type mice. Thus, IRF-1 is essential for iNOS activation in murine macrophages. |
Persistent Identifier | http://hdl.handle.net/10722/292449 |
ISSN | 2023 Impact Factor: 44.7 2023 SCImago Journal Rankings: 11.902 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Kamijo, R. | - |
dc.contributor.author | Harada, H. | - |
dc.contributor.author | Matsuyama, T. | - |
dc.contributor.author | Bosland, M. | - |
dc.contributor.author | Gerecitano, J. | - |
dc.contributor.author | Shapiro, D. | - |
dc.contributor.author | Le, J. | - |
dc.contributor.author | Koh, S. I. | - |
dc.contributor.author | Kimura, T. | - |
dc.contributor.author | Green, S. J. | - |
dc.contributor.author | Mak, T. W. | - |
dc.contributor.author | Taniguchi, T. | - |
dc.contributor.author | Vilček, J. | - |
dc.date.accessioned | 2020-11-17T14:56:30Z | - |
dc.date.available | 2020-11-17T14:56:30Z | - |
dc.date.issued | 1994 | - |
dc.identifier.citation | Science, 1994, v. 263, n. 5153, p. 1612-1615 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292449 | - |
dc.description.abstract | Production of nitric oxide (NO) by macrophages is important for the killing of intracellular infectious agents. Interferon (IFN)-γ and lipopolysaccharide stimulate NO production by transcriptionally up-regulating the inducible NO synthase (iNOS). Macrophages from mice with a targeted disruption of the IFN regulatory factor-1 (IRF-1) gene (IRF-I-/- mice) produced little or no NO and synthesized barely detectable iNOS messenger RNA in response to stimulation. Two adjacent IRF-1 response elements were identified in the iNOS promoter. Infection with Mycobacterium bovis (BCG) was more severe in IRF-1-/- mice than in wild-type mice. Thus, IRF-1 is essential for iNOS activation in murine macrophages. | - |
dc.language | eng | - |
dc.relation.ispartof | Science | - |
dc.title | Requirement for transcription factor IRF-1 in NO synthase induction in macrophages | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1126/science.7510419 | - |
dc.identifier.pmid | 7510419 | - |
dc.identifier.scopus | eid_2-s2.0-0028348307 | - |
dc.identifier.volume | 263 | - |
dc.identifier.issue | 5153 | - |
dc.identifier.spage | 1612 | - |
dc.identifier.epage | 1615 | - |
dc.identifier.isi | WOS:A1994NB67300032 | - |
dc.identifier.issnl | 0036-8075 | - |