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Article: CD28 signals through acidic sphingomyelinase

TitleCD28 signals through acidic sphingomyelinase
Authors
Issue Date1995
Citation
Journal of Experimental Medicine, 1995, v. 181, n. 6, p. 2059-2068 How to Cite?
AbstractT cell receptor recognition of antigen can lead either to T lymphocyte differentiation and proliferation or to a state of unresponsiveness, which is dependent on whether appropriate costimulatory signals are provided to the mature T cell. We have investigated a novel intracellular signaling pathway provided by the costimulatory molecule CD28. CD28 engagement triggers the activation of an acidic sphingomyelinase (A-SMase), which results in the generation of ceramide, an important lipid messenger intc-i-ediate. A-SMase activation by CD28 occurred in resting as well as in activated primary T cells or leukemic Jurkat cells. In contrast, ligation of either CD3 or CD2 did not result in A-SMase activation. Overexpression of recombinant A-SMase in Jurkat T cells substituted for CD28 with regard to nuclear factor-gB activation. These data suggest that CD28 provides an important costimulatory signal by activation of an acidic sphingomyelinase pathway. © 1995, Rockefeller University Press., All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/292467
ISSN
2023 Impact Factor: 12.6
2023 SCImago Journal Rankings: 6.838
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBoucher, Louis Martin-
dc.contributor.authorWiegmann, Katja-
dc.contributor.authorFütterer, Agnes-
dc.contributor.authorPfeffer, Klaus-
dc.contributor.authorMachleidt, Thomas-
dc.contributor.authorSchtitze, Stefan-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorKrönke, Martin-
dc.date.accessioned2020-11-17T14:56:33Z-
dc.date.available2020-11-17T14:56:33Z-
dc.date.issued1995-
dc.identifier.citationJournal of Experimental Medicine, 1995, v. 181, n. 6, p. 2059-2068-
dc.identifier.issn0022-1007-
dc.identifier.urihttp://hdl.handle.net/10722/292467-
dc.description.abstractT cell receptor recognition of antigen can lead either to T lymphocyte differentiation and proliferation or to a state of unresponsiveness, which is dependent on whether appropriate costimulatory signals are provided to the mature T cell. We have investigated a novel intracellular signaling pathway provided by the costimulatory molecule CD28. CD28 engagement triggers the activation of an acidic sphingomyelinase (A-SMase), which results in the generation of ceramide, an important lipid messenger intc-i-ediate. A-SMase activation by CD28 occurred in resting as well as in activated primary T cells or leukemic Jurkat cells. In contrast, ligation of either CD3 or CD2 did not result in A-SMase activation. Overexpression of recombinant A-SMase in Jurkat T cells substituted for CD28 with regard to nuclear factor-gB activation. These data suggest that CD28 provides an important costimulatory signal by activation of an acidic sphingomyelinase pathway. © 1995, Rockefeller University Press., All rights reserved.-
dc.languageeng-
dc.relation.ispartofJournal of Experimental Medicine-
dc.titleCD28 signals through acidic sphingomyelinase-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1084/jem.181.6.2059-
dc.identifier.pmid7759998-
dc.identifier.pmcidPMC2192051-
dc.identifier.scopuseid_2-s2.0-0029036715-
dc.identifier.volume181-
dc.identifier.issue6-
dc.identifier.spage2059-
dc.identifier.epage2068-
dc.identifier.eissn1540-9538-
dc.identifier.isiWOS:A1995RA60500014-
dc.identifier.issnl0022-1007-

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