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Article: Essential and non-redundant roles of p48 (ISGF3γ) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies

TitleEssential and non-redundant roles of p48 (ISGF3γ) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies
Authors
Issue Date1996
Citation
Genes to Cells, 1996, v. 1, n. 1, p. 115-124 How to Cite?
AbstractBackground: Interferons (IFNs) are a class of cytokines which confer cellular resistance against viral infections. Type I (IFN-α and -β) and type II (IFN-γ) IFNs utilize distinct receptors, the stimulation of which results in the induction of down-stream target genes. These target genes usually contain within their promoter region an IFN responsive element, termed ISRE (IFN stimulated response element) which binds a heterotrimeric transcription factor, ISGF3 (IFN-stimulated gene factor 3) consisting of p48 (ISGF3 γ), Stat1 (Signal transducers and activators of transcription-1; α or β), and Stat2. The ISRE sequence overlaps with that of IRF-E which binds another IFN-inducible factor, IRF-1 (IFN regulatory factor-1). Results: We generated mice lacking p48 by gene targeting. We show that p48 plays an essential role in both type I and type II IFN responses; activation of IFN-inducible genes and establishment of the antiviral state by IFN-α or -γ are both severely impaired, and ISRE-binding activities induced by both IFNs are absent in the p48-negative embryonic fibroblasts (EFs). Furthermore, we generated mice deficient for both p48 and IRF-1 and found that at least one IFN-inducible gene is dependent on both factors. Conclusions: p48 and IRF-1 do not perform redundant functions in the cell, but rather complement one another in both type I and II IFN responses. © Blackwell Science Limited.
Persistent Identifierhttp://hdl.handle.net/10722/292490
ISSN
2023 Impact Factor: 1.3
2023 SCImago Journal Rankings: 0.662
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKimura, Tohru-
dc.contributor.authorKadokawa, Yuzo-
dc.contributor.authorHarada, Hisashi-
dc.contributor.authorMatsumoto, Masahito-
dc.contributor.authorSato, Mitsuharu-
dc.contributor.authorKashiwazaki, Yasuo-
dc.contributor.authorTarutani, Masahito-
dc.contributor.authorTan, Rosemary Sok Pin-
dc.contributor.authorTakasugi, Tomohiro-
dc.contributor.authorMatsuyama, Toshifumi-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorNoguchi, Shigeru-
dc.contributor.authorTaniguchi, Tadatsugu-
dc.date.accessioned2020-11-17T14:56:35Z-
dc.date.available2020-11-17T14:56:35Z-
dc.date.issued1996-
dc.identifier.citationGenes to Cells, 1996, v. 1, n. 1, p. 115-124-
dc.identifier.issn1356-9597-
dc.identifier.urihttp://hdl.handle.net/10722/292490-
dc.description.abstractBackground: Interferons (IFNs) are a class of cytokines which confer cellular resistance against viral infections. Type I (IFN-α and -β) and type II (IFN-γ) IFNs utilize distinct receptors, the stimulation of which results in the induction of down-stream target genes. These target genes usually contain within their promoter region an IFN responsive element, termed ISRE (IFN stimulated response element) which binds a heterotrimeric transcription factor, ISGF3 (IFN-stimulated gene factor 3) consisting of p48 (ISGF3 γ), Stat1 (Signal transducers and activators of transcription-1; α or β), and Stat2. The ISRE sequence overlaps with that of IRF-E which binds another IFN-inducible factor, IRF-1 (IFN regulatory factor-1). Results: We generated mice lacking p48 by gene targeting. We show that p48 plays an essential role in both type I and type II IFN responses; activation of IFN-inducible genes and establishment of the antiviral state by IFN-α or -γ are both severely impaired, and ISRE-binding activities induced by both IFNs are absent in the p48-negative embryonic fibroblasts (EFs). Furthermore, we generated mice deficient for both p48 and IRF-1 and found that at least one IFN-inducible gene is dependent on both factors. Conclusions: p48 and IRF-1 do not perform redundant functions in the cell, but rather complement one another in both type I and II IFN responses. © Blackwell Science Limited.-
dc.languageeng-
dc.relation.ispartofGenes to Cells-
dc.titleEssential and non-redundant roles of p48 (ISGF3γ) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1046/j.1365-2443.1996.08008.x-
dc.identifier.pmid9078371-
dc.identifier.scopuseid_2-s2.0-0029678749-
dc.identifier.volume1-
dc.identifier.issue1-
dc.identifier.spage115-
dc.identifier.epage124-
dc.identifier.isiWOS:A1996VC84200011-
dc.identifier.issnl1356-9597-

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