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- Publisher Website: 10.1073/pnas.0337707100
- Scopus: eid_2-s2.0-0037417885
- PMID: 12538858
- WOS: WOS:000180838100079
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Article: The role of nuclear factor-κB essential modulator (NEMO) in B cell development and survival
Title | The role of nuclear factor-κB essential modulator (NEMO) in B cell development and survival |
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Authors | |
Issue Date | 2003 |
Citation | Proceedings of the National Academy of Sciences of the United States of America, 2003, v. 100, n. 3, p. 1203-1208 How to Cite? |
Abstract | The transcription factor nuclear factor-κB (NF-κB) is essential for immune and inflammatory responses. NF-κB essential modulator (NEMO) is a scaffolding component of the IκB kinase complex required for NF-κB activation in vitro. Because NF-κB activation is involved in B cell development and function, we set out to determine whether NEMO is required for these processes. NEMO(-/-) mice die very early during embryogenesis, and fetal livers from NEMO(-/-) embryos can not reconstitute either B or T lymphopoiesis in irradiated host mice. We therefore used NEMO(-/-) embryonic stem cells and the OP9 in vitro differentiation system to demonstrate that NEMO is not required for B cell development but plays an important role in B cell survival. |
Persistent Identifier | http://hdl.handle.net/10722/292521 |
ISSN | 2023 Impact Factor: 9.4 2023 SCImago Journal Rankings: 3.737 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Kim, Shinyop | - |
dc.contributor.author | La Motte-Mohs, Ross N.A. | - |
dc.contributor.author | Rudolph, Dorothea | - |
dc.contributor.author | Zúñiga-Pflücker, Juan Carlos | - |
dc.contributor.author | Mak, Tak W. | - |
dc.date.accessioned | 2020-11-17T14:56:39Z | - |
dc.date.available | 2020-11-17T14:56:39Z | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the United States of America, 2003, v. 100, n. 3, p. 1203-1208 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292521 | - |
dc.description.abstract | The transcription factor nuclear factor-κB (NF-κB) is essential for immune and inflammatory responses. NF-κB essential modulator (NEMO) is a scaffolding component of the IκB kinase complex required for NF-κB activation in vitro. Because NF-κB activation is involved in B cell development and function, we set out to determine whether NEMO is required for these processes. NEMO(-/-) mice die very early during embryogenesis, and fetal livers from NEMO(-/-) embryos can not reconstitute either B or T lymphopoiesis in irradiated host mice. We therefore used NEMO(-/-) embryonic stem cells and the OP9 in vitro differentiation system to demonstrate that NEMO is not required for B cell development but plays an important role in B cell survival. | - |
dc.language | eng | - |
dc.relation.ispartof | Proceedings of the National Academy of Sciences of the United States of America | - |
dc.title | The role of nuclear factor-κB essential modulator (NEMO) in B cell development and survival | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1073/pnas.0337707100 | - |
dc.identifier.pmid | 12538858 | - |
dc.identifier.pmcid | PMC298751 | - |
dc.identifier.scopus | eid_2-s2.0-0037417885 | - |
dc.identifier.volume | 100 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 1203 | - |
dc.identifier.epage | 1208 | - |
dc.identifier.isi | WOS:000180838100079 | - |
dc.identifier.issnl | 0027-8424 | - |