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Article: Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells

TitleCritical role of leukocyte function-associated antigen-1 in liver accumulation of CD4<sup>+</sup>NKT cells
Authors
Issue Date1999
Citation
Journal of Immunology, 1999, v. 162, n. 9, p. 5094-5098 How to Cite?
AbstractIn contrast to peripheral lymphoid organs, a high percentage of T cells in the liver are CD4+NKT cells. We asked whether adhesion molecules play any role in the accumulation of CD4+NKT cells in the liver. Liver CD4+NKT cells expressed ICAM-1 and high levels of LFA-1. In the livers of LFA-l-deficient mice, the number of CD4+NKT cells was markedly decreased. This reduction was restricted to the liver, and no reduction was found in the other organs analyzed. In contrast, the number of liver CD4+NKT cells in ICAM-l-deficient mice was only marginally reduced. In a reciprocal radiation thymocyte reconstitution system with LFA-l-deficient and wild-type mice, LFA-1 expressed on liver cells other than CD4+NKT cells was required for an accumulation of CD4+NKT cells in the liver. These results demonstrate a crucial role for LFA-1 in the accumulation of CD4+NKT cells in the liver.
Persistent Identifierhttp://hdl.handle.net/10722/292528
ISSN
2023 Impact Factor: 3.6
2023 SCImago Journal Rankings: 1.558
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorEmoto, Masashi-
dc.contributor.authorMittrücker, Hans Willi-
dc.contributor.authorSchmits, Rudolf-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorKaufmann, Stefan H.E.-
dc.date.accessioned2020-11-17T14:56:40Z-
dc.date.available2020-11-17T14:56:40Z-
dc.date.issued1999-
dc.identifier.citationJournal of Immunology, 1999, v. 162, n. 9, p. 5094-5098-
dc.identifier.issn0022-1767-
dc.identifier.urihttp://hdl.handle.net/10722/292528-
dc.description.abstractIn contrast to peripheral lymphoid organs, a high percentage of T cells in the liver are CD4+NKT cells. We asked whether adhesion molecules play any role in the accumulation of CD4+NKT cells in the liver. Liver CD4+NKT cells expressed ICAM-1 and high levels of LFA-1. In the livers of LFA-l-deficient mice, the number of CD4+NKT cells was markedly decreased. This reduction was restricted to the liver, and no reduction was found in the other organs analyzed. In contrast, the number of liver CD4+NKT cells in ICAM-l-deficient mice was only marginally reduced. In a reciprocal radiation thymocyte reconstitution system with LFA-l-deficient and wild-type mice, LFA-1 expressed on liver cells other than CD4+NKT cells was required for an accumulation of CD4+NKT cells in the liver. These results demonstrate a crucial role for LFA-1 in the accumulation of CD4+NKT cells in the liver.-
dc.languageeng-
dc.relation.ispartofJournal of Immunology-
dc.titleCritical role of leukocyte function-associated antigen-1 in liver accumulation of CD4<sup>+</sup>NKT cells-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid10227978-
dc.identifier.scopuseid_2-s2.0-0344759113-
dc.identifier.volume162-
dc.identifier.issue9-
dc.identifier.spage5094-
dc.identifier.epage5098-
dc.identifier.isiWOS:000079892600012-
dc.identifier.issnl0022-1767-

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