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Article: Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways

TitleCoordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways
Authors
KeywordsPathway, interactions
p53-AKT
p53-TOR
Issue Date2006
Citation
Genes and Development, 2006, v. 20, n. 3, p. 267-275 How to Cite?
AbstractOver the past 10 years the signal transduction networks for p53, IGF-1-AKT, and TOR pathways have been assembled in worms, flies, and mammals, and their functions elucidated. In the past 1-2 years a number of genes and their proteins have been identified that permit extensive communication and coordination between these pathways. These three pathways are involved in sensing and integrating signals arising from nutrient and growth factor availability, signals from sensory and sexual organs, and intrinsic and extrinsic stress signals. In turn these pathways regulate cell growth, proliferation, and death. These networks are central to our understanding of a variety of physiological and pathological conditions, including cancer, diabetes, and longevity. © 2006 by Cold Spring Harbor Laboratory Press.
Persistent Identifierhttp://hdl.handle.net/10722/292565
ISSN
2020 Impact Factor: 11.361
2020 SCImago Journal Rankings: 7.136
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLevine, Arnold J.-
dc.contributor.authorFeng, Zhaohui-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorYou, Han-
dc.contributor.authorJin, Shengkan-
dc.date.accessioned2020-11-17T14:56:45Z-
dc.date.available2020-11-17T14:56:45Z-
dc.date.issued2006-
dc.identifier.citationGenes and Development, 2006, v. 20, n. 3, p. 267-275-
dc.identifier.issn0890-9369-
dc.identifier.urihttp://hdl.handle.net/10722/292565-
dc.description.abstractOver the past 10 years the signal transduction networks for p53, IGF-1-AKT, and TOR pathways have been assembled in worms, flies, and mammals, and their functions elucidated. In the past 1-2 years a number of genes and their proteins have been identified that permit extensive communication and coordination between these pathways. These three pathways are involved in sensing and integrating signals arising from nutrient and growth factor availability, signals from sensory and sexual organs, and intrinsic and extrinsic stress signals. In turn these pathways regulate cell growth, proliferation, and death. These networks are central to our understanding of a variety of physiological and pathological conditions, including cancer, diabetes, and longevity. © 2006 by Cold Spring Harbor Laboratory Press.-
dc.languageeng-
dc.relation.ispartofGenes and Development-
dc.subjectPathway, interactions-
dc.subjectp53-AKT-
dc.subjectp53-TOR-
dc.titleCoordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1101/gad.1363206-
dc.identifier.pmid16452501-
dc.identifier.scopuseid_2-s2.0-32044435126-
dc.identifier.volume20-
dc.identifier.issue3-
dc.identifier.spage267-
dc.identifier.epage275-
dc.identifier.eissn1549-5477-
dc.identifier.isiWOS:000235267000001-
dc.identifier.issnl0890-9369-

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