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- Publisher Website: 10.1101/gad.1363206
- Scopus: eid_2-s2.0-32044435126
- PMID: 16452501
- WOS: WOS:000235267000001
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Article: Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways
Title | Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways |
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Authors | |
Keywords | Pathway, interactions p53-AKT p53-TOR |
Issue Date | 2006 |
Citation | Genes and Development, 2006, v. 20, n. 3, p. 267-275 How to Cite? |
Abstract | Over the past 10 years the signal transduction networks for p53, IGF-1-AKT, and TOR pathways have been assembled in worms, flies, and mammals, and their functions elucidated. In the past 1-2 years a number of genes and their proteins have been identified that permit extensive communication and coordination between these pathways. These three pathways are involved in sensing and integrating signals arising from nutrient and growth factor availability, signals from sensory and sexual organs, and intrinsic and extrinsic stress signals. In turn these pathways regulate cell growth, proliferation, and death. These networks are central to our understanding of a variety of physiological and pathological conditions, including cancer, diabetes, and longevity. © 2006 by Cold Spring Harbor Laboratory Press. |
Persistent Identifier | http://hdl.handle.net/10722/292565 |
ISSN | 2023 Impact Factor: 7.5 2023 SCImago Journal Rankings: 5.015 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Levine, Arnold J. | - |
dc.contributor.author | Feng, Zhaohui | - |
dc.contributor.author | Mak, Tak W. | - |
dc.contributor.author | You, Han | - |
dc.contributor.author | Jin, Shengkan | - |
dc.date.accessioned | 2020-11-17T14:56:45Z | - |
dc.date.available | 2020-11-17T14:56:45Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Genes and Development, 2006, v. 20, n. 3, p. 267-275 | - |
dc.identifier.issn | 0890-9369 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292565 | - |
dc.description.abstract | Over the past 10 years the signal transduction networks for p53, IGF-1-AKT, and TOR pathways have been assembled in worms, flies, and mammals, and their functions elucidated. In the past 1-2 years a number of genes and their proteins have been identified that permit extensive communication and coordination between these pathways. These three pathways are involved in sensing and integrating signals arising from nutrient and growth factor availability, signals from sensory and sexual organs, and intrinsic and extrinsic stress signals. In turn these pathways regulate cell growth, proliferation, and death. These networks are central to our understanding of a variety of physiological and pathological conditions, including cancer, diabetes, and longevity. © 2006 by Cold Spring Harbor Laboratory Press. | - |
dc.language | eng | - |
dc.relation.ispartof | Genes and Development | - |
dc.subject | Pathway, interactions | - |
dc.subject | p53-AKT | - |
dc.subject | p53-TOR | - |
dc.title | Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1101/gad.1363206 | - |
dc.identifier.pmid | 16452501 | - |
dc.identifier.scopus | eid_2-s2.0-32044435126 | - |
dc.identifier.volume | 20 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 267 | - |
dc.identifier.epage | 275 | - |
dc.identifier.eissn | 1549-5477 | - |
dc.identifier.isi | WOS:000235267000001 | - |
dc.identifier.issnl | 0890-9369 | - |