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Article: FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal

TitleFOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal
Authors
Issue Date2006
Citation
Journal of Experimental Medicine, 2006, v. 203, n. 7, p. 1657-1663 How to Cite?
AbstractPuma is an essential mediator of p53-dependent and -independent apoptosis in vivo. In response to genotoxic stress, Puma is induced in a p53-dependent manner. However, the transcription factor driving Puma up-regulation in response to p53-independent apoptotic stimuli has yet to be identified. Here, we show that FOXO3a up-regulates Puma expression in response to cytokine or growth factor deprivation. Importantly, dysregulated Akt signaling in lymphoid cells attenuated Puma induction upon cytokine withdrawal. Our results suggest that Puma, together with another BH3 only member, Bim, function as FOXO3a downstream targets to mediate a stress response when PI3K/Akt signaling is down-regulated. JEM © The Rockefeller University Press.
Persistent Identifierhttp://hdl.handle.net/10722/292575
ISSN
2020 Impact Factor: 14.307
2020 SCImago Journal Rankings: 8.483
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYou, Han-
dc.contributor.authorPellegrini, Marc-
dc.contributor.authorTsuchihara, Katsuya-
dc.contributor.authorYamamoto, Kazuo-
dc.contributor.authorHacker, Georg-
dc.contributor.authorErlacher, Miriam-
dc.contributor.authorVillunger, Andreas-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:56:46Z-
dc.date.available2020-11-17T14:56:46Z-
dc.date.issued2006-
dc.identifier.citationJournal of Experimental Medicine, 2006, v. 203, n. 7, p. 1657-1663-
dc.identifier.issn0022-1007-
dc.identifier.urihttp://hdl.handle.net/10722/292575-
dc.description.abstractPuma is an essential mediator of p53-dependent and -independent apoptosis in vivo. In response to genotoxic stress, Puma is induced in a p53-dependent manner. However, the transcription factor driving Puma up-regulation in response to p53-independent apoptotic stimuli has yet to be identified. Here, we show that FOXO3a up-regulates Puma expression in response to cytokine or growth factor deprivation. Importantly, dysregulated Akt signaling in lymphoid cells attenuated Puma induction upon cytokine withdrawal. Our results suggest that Puma, together with another BH3 only member, Bim, function as FOXO3a downstream targets to mediate a stress response when PI3K/Akt signaling is down-regulated. JEM © The Rockefeller University Press.-
dc.languageeng-
dc.relation.ispartofJournal of Experimental Medicine-
dc.titleFOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1084/jem.20060353-
dc.identifier.pmid16801400-
dc.identifier.pmcidPMC2118330-
dc.identifier.scopuseid_2-s2.0-33745841375-
dc.identifier.volume203-
dc.identifier.issue7-
dc.identifier.spage1657-
dc.identifier.epage1663-
dc.identifier.eissn0022-1007-
dc.identifier.isiWOS:000238940500007-
dc.identifier.issnl0022-1007-

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