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- Publisher Website: 10.1016/j.cell.2006.06.039
- Scopus: eid_2-s2.0-33746766974
- PMID: 16901786
- WOS: WOS:000239883400013
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Article: A Role for the Deubiquitinating Enzyme USP28 in Control of the DNA-Damage Response
Title | A Role for the Deubiquitinating Enzyme USP28 in Control of the DNA-Damage Response |
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Authors | |
Issue Date | 2006 |
Citation | Cell, 2006, v. 126, n. 3, p. 529-542 How to Cite? |
Abstract | The Chk2-p53-PUMA pathway is a major regulator of DNA-damage-induced apoptosis in response to double-strand breaks in vivo. Through analysis of 53BP1 complexes we have discovered a new ubiquitin protease, USP28, which regulates this pathway. Using a human cell line that faithfully recapitulated the Chk2-p53-PUMA pathway, we show that USP28 is required to stabilize Chk2 and 53BP1 in response to DNA damage. In this cell line, both USP28 and Chk2 are required for DNA-damage-induced apoptosis, and they accomplish this in part through regulation of the p53 induction of proapoptotic genes like PUMA. Our studies implicate DNA-damage-induced ubiquitination and deubiquitination as a major regulator of the DNA-damage response for Chk2, 53BP1, and a number of other proteins in the DNA-damage checkpoint pathway, including several mediators, such as Mdc1, Claspin, and TopBP1. © 2006 Elsevier Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/292580 |
ISSN | 2023 Impact Factor: 45.5 2023 SCImago Journal Rankings: 24.342 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zhang, Dong | - |
dc.contributor.author | Zaugg, Kathrin | - |
dc.contributor.author | Mak, Tak W. | - |
dc.contributor.author | Elledge, Stephen J. | - |
dc.date.accessioned | 2020-11-17T14:56:47Z | - |
dc.date.available | 2020-11-17T14:56:47Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Cell, 2006, v. 126, n. 3, p. 529-542 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292580 | - |
dc.description.abstract | The Chk2-p53-PUMA pathway is a major regulator of DNA-damage-induced apoptosis in response to double-strand breaks in vivo. Through analysis of 53BP1 complexes we have discovered a new ubiquitin protease, USP28, which regulates this pathway. Using a human cell line that faithfully recapitulated the Chk2-p53-PUMA pathway, we show that USP28 is required to stabilize Chk2 and 53BP1 in response to DNA damage. In this cell line, both USP28 and Chk2 are required for DNA-damage-induced apoptosis, and they accomplish this in part through regulation of the p53 induction of proapoptotic genes like PUMA. Our studies implicate DNA-damage-induced ubiquitination and deubiquitination as a major regulator of the DNA-damage response for Chk2, 53BP1, and a number of other proteins in the DNA-damage checkpoint pathway, including several mediators, such as Mdc1, Claspin, and TopBP1. © 2006 Elsevier Inc. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Cell | - |
dc.title | A Role for the Deubiquitinating Enzyme USP28 in Control of the DNA-Damage Response | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1016/j.cell.2006.06.039 | - |
dc.identifier.pmid | 16901786 | - |
dc.identifier.scopus | eid_2-s2.0-33746766974 | - |
dc.identifier.volume | 126 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 529 | - |
dc.identifier.epage | 542 | - |
dc.identifier.isi | WOS:000239883400013 | - |
dc.identifier.issnl | 0092-8674 | - |