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- Publisher Website: 10.1016/j.molcel.2011.08.038
- Scopus: eid_2-s2.0-80555135898
- PMID: 22055193
- WOS: WOS:000296756100015
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Article: ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress
Title | ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress |
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Authors | |
Issue Date | 2011 |
Citation | Molecular Cell, 2011, v. 44, n. 3, p. 491-501 How to Cite? |
Abstract | The p53 protein is activated by stress signals and exhibits both protective and death-promoting functions that are considered important for its tumor suppressor function. Emerging evidence points toward an additional role for p53 in metabolism. Here, we identify Lpin1 as a p53-responsive gene that is induced in response to DNA damage and glucose deprivation. Lpin1 is essential for adipocyte development and fat metabolism, and mutation in this gene is responsible for the lypodystrophy phenotype in fld mice. We show that p53 and Lpin1 regulate fatty acid oxidation in mouse C2C12 myoblasts. p53 phosphorylation on Ser18 in response to low glucose is ROS and ATM dependent. Lpin1 expression in response to nutritional stress is controlled through the ROS-ATM-p53 pathway and is conserved in human cells. Lpin1 provides a critical link between p53 and metabolism that may be an important component in mediating the tumor suppressor function of p53. © 2011 Elsevier Inc. |
Persistent Identifier | http://hdl.handle.net/10722/292666 |
ISSN | 2023 Impact Factor: 14.5 2023 SCImago Journal Rankings: 9.332 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Assaily, Wissam | - |
dc.contributor.author | Rubinger, Daniel A. | - |
dc.contributor.author | Wheaton, Keith | - |
dc.contributor.author | Lin, Yunping | - |
dc.contributor.author | Ma, Weili | - |
dc.contributor.author | Xuan, Wanli | - |
dc.contributor.author | Brown-Endres, Lauren | - |
dc.contributor.author | Tsuchihara, Katsuya | - |
dc.contributor.author | Mak, Tak W. | - |
dc.contributor.author | Benchimol, Samuel | - |
dc.date.accessioned | 2020-11-17T14:56:58Z | - |
dc.date.available | 2020-11-17T14:56:58Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Molecular Cell, 2011, v. 44, n. 3, p. 491-501 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292666 | - |
dc.description.abstract | The p53 protein is activated by stress signals and exhibits both protective and death-promoting functions that are considered important for its tumor suppressor function. Emerging evidence points toward an additional role for p53 in metabolism. Here, we identify Lpin1 as a p53-responsive gene that is induced in response to DNA damage and glucose deprivation. Lpin1 is essential for adipocyte development and fat metabolism, and mutation in this gene is responsible for the lypodystrophy phenotype in fld mice. We show that p53 and Lpin1 regulate fatty acid oxidation in mouse C2C12 myoblasts. p53 phosphorylation on Ser18 in response to low glucose is ROS and ATM dependent. Lpin1 expression in response to nutritional stress is controlled through the ROS-ATM-p53 pathway and is conserved in human cells. Lpin1 provides a critical link between p53 and metabolism that may be an important component in mediating the tumor suppressor function of p53. © 2011 Elsevier Inc. | - |
dc.language | eng | - |
dc.relation.ispartof | Molecular Cell | - |
dc.title | ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1016/j.molcel.2011.08.038 | - |
dc.identifier.pmid | 22055193 | - |
dc.identifier.scopus | eid_2-s2.0-80555135898 | - |
dc.identifier.volume | 44 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 491 | - |
dc.identifier.epage | 501 | - |
dc.identifier.eissn | 1097-4164 | - |
dc.identifier.isi | WOS:000296756100015 | - |
dc.identifier.issnl | 1097-2765 | - |