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Article: Matrix metalloproteinase 9 mRNA: An early prognostic marker for patients with acute stroke

TitleMatrix metalloproteinase 9 mRNA: An early prognostic marker for patients with acute stroke
Authors
Graham, Colin A.Chan, Rebecca W.Y.Chan, Dexter Y.S.Chan, Cangel P.Y.Wong, Lawrence K.S.Rainer, Timothy H.
KeywordsBlood-brain barrier
Matrix metalloproteinase 9 (MMP9)
Messenger RNA (mRNA)
Stroke
Prognostic
Issue Date2012
Citation
Clinical Biochemistry, 2012, v. 45, n. 4-5, p. 352-355 How to Cite?
DOI: http://dx.doi.org/10.1016/j.clinbiochem.2011.12.006
AbstractObjectives: To investigate matrix metalloproteinase 9 (MMP9) mRNA as a prognostic marker in stroke. Design and methods: MMP9 mRNA concentrations in 126 stroke patients were analyzed using quantitative reverse transcription-polymerase chain reaction. Results: The normalized MMP9 mRNA concentration was almost 3 times higher in non-survival patients compared to survival patients (P=0.0002); and 1.9-fold higher in patients with post-stroke modified Rankin score (mRS) > 2 than patients with mRS ≤ 2 (P< 0.05). Conclusions: MMP9 mRNA was a predictor of poor outcome and mortality in stroke. © 2011 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/292689
ISSN
0009-9120
2023 Impact Factor: 2.5
2023 SCImago Journal Rankings: 0.703
ISI Accession Number ID
WOS:000302844500015

 

DC FieldValueLanguage
dc.contributor.authorGraham, Colin A.-
dc.contributor.authorChan, Rebecca W.Y.-
dc.contributor.authorChan, Dexter Y.S.-
dc.contributor.authorChan, Cangel P.Y.-
dc.contributor.authorWong, Lawrence K.S.-
dc.contributor.authorRainer, Timothy H.-
dc.date.accessioned2020-11-17T14:57:01Z-
dc.date.available2020-11-17T14:57:01Z-
dc.date.issued2012-
dc.identifier.citationClinical Biochemistry, 2012, v. 45, n. 4-5, p. 352-355-
dc.identifier.issn0009-9120-
dc.identifier.urihttp://hdl.handle.net/10722/292689-
dc.description.abstractObjectives: To investigate matrix metalloproteinase 9 (MMP9) mRNA as a prognostic marker in stroke. Design and methods: MMP9 mRNA concentrations in 126 stroke patients were analyzed using quantitative reverse transcription-polymerase chain reaction. Results: The normalized MMP9 mRNA concentration was almost 3 times higher in non-survival patients compared to survival patients (P=0.0002); and 1.9-fold higher in patients with post-stroke modified Rankin score (mRS) > 2 than patients with mRS ≤ 2 (P< 0.05). Conclusions: MMP9 mRNA was a predictor of poor outcome and mortality in stroke. © 2011 Elsevier Inc.-
dc.languageeng-
dc.relation.ispartofClinical Biochemistry-
dc.subjectBlood-brain barrier-
dc.subjectMatrix metalloproteinase 9 (MMP9)-
dc.subjectMessenger RNA (mRNA)-
dc.subjectStroke-
dc.subjectPrognostic-
dc.titleMatrix metalloproteinase 9 mRNA: An early prognostic marker for patients with acute stroke-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.clinbiochem.2011.12.006-
dc.identifier.pmid22200563-
dc.identifier.scopuseid_2-s2.0-84857649421-
dc.identifier.volume45-
dc.identifier.issue4-5-
dc.identifier.spage352-
dc.identifier.epage355-
dc.identifier.eissn1873-2933-
dc.identifier.isiWOS:000302844500015-
dc.identifier.issnl0009-9120-

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