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Article: Multiple atherosclerosis-related biomarkers associated with short- and long-term mortality after stroke

TitleMultiple atherosclerosis-related biomarkers associated with short- and long-term mortality after stroke
Authors
KeywordsHigh-sensitivity C-reactive protein (hs-CRP)
Myeloperoxidase (MPO)
Lipocalin-2 (LCN2)
Matrix metalloproteinase 9 (MMP9)
Mortality
Stroke
Issue Date2012
Citation
Clinical Biochemistry, 2012, v. 45, n. 16-17, p. 1308-1315 How to Cite?
AbstractObjectives: We investigated the relationships of biomarkers of various pathophysiologic pathways including high-sensitivity C-reactive protein (hs-CRP), lipocalin-2 (LCN2), myeloperoxidase (MPO) and matrix metalloproteinases 9 (MMP9) with mortality in stroke patients. Design and methods: hs-CRP, LCN2 and MPO concentrations in 92 patients were determined using enzyme-linked immunosorbent assays. MMP9 mRNA concentrations were determined using real-time quantitative reverse transcription-polymerase chain reaction. Results: Twelve patients (13.0%) died at 6. months and 34 patients (37.0%) died at 5. years. The independent predictors for 6-month mortality were hs-CRP (adjusted OR = 16.0) and LCN2 (adjusted OR = 16.9), while for 5-year mortality was hs-CRP (adjusted OR = 5.56). For patients with hs-CRP >. 3.4. mg/L, an increase in LCN2 was associated with 2.5-fold higher 6-month mortality, while an increase in normalized MMP9 mRNA was associated with 5.8-fold higher 6-month and 1.5-fold higher 5-year mortality. Conclusion: hs-CRP was the most significant independent predictor of both short- and long-term mortality after stroke, with LCN2 and MMP9 mRNA each adding further to the risk stratification. © 2012 The Canadian Society of Clinical Chemists.
Persistent Identifierhttp://hdl.handle.net/10722/292732
ISSN
2020 Impact Factor: 3.281
2020 SCImago Journal Rankings: 0.756
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, Cangel Pui Yee-
dc.contributor.authorJiang, Hui Lin-
dc.contributor.authorLeung, Ling Yan-
dc.contributor.authorWan, Wai Man-
dc.contributor.authorCheng, Nga Man-
dc.contributor.authorIp, Wai Sze-
dc.contributor.authorCheung, Kwan Yee-
dc.contributor.authorChan, Rebecca Wing Yan-
dc.contributor.authorWong, Lawrence Ka Sing-
dc.contributor.authorGraham, Colin Alexander-
dc.contributor.authorRenneberg, Reinhard-
dc.contributor.authorRainer, Timothy Hudson-
dc.date.accessioned2020-11-17T14:57:06Z-
dc.date.available2020-11-17T14:57:06Z-
dc.date.issued2012-
dc.identifier.citationClinical Biochemistry, 2012, v. 45, n. 16-17, p. 1308-1315-
dc.identifier.issn0009-9120-
dc.identifier.urihttp://hdl.handle.net/10722/292732-
dc.description.abstractObjectives: We investigated the relationships of biomarkers of various pathophysiologic pathways including high-sensitivity C-reactive protein (hs-CRP), lipocalin-2 (LCN2), myeloperoxidase (MPO) and matrix metalloproteinases 9 (MMP9) with mortality in stroke patients. Design and methods: hs-CRP, LCN2 and MPO concentrations in 92 patients were determined using enzyme-linked immunosorbent assays. MMP9 mRNA concentrations were determined using real-time quantitative reverse transcription-polymerase chain reaction. Results: Twelve patients (13.0%) died at 6. months and 34 patients (37.0%) died at 5. years. The independent predictors for 6-month mortality were hs-CRP (adjusted OR = 16.0) and LCN2 (adjusted OR = 16.9), while for 5-year mortality was hs-CRP (adjusted OR = 5.56). For patients with hs-CRP >. 3.4. mg/L, an increase in LCN2 was associated with 2.5-fold higher 6-month mortality, while an increase in normalized MMP9 mRNA was associated with 5.8-fold higher 6-month and 1.5-fold higher 5-year mortality. Conclusion: hs-CRP was the most significant independent predictor of both short- and long-term mortality after stroke, with LCN2 and MMP9 mRNA each adding further to the risk stratification. © 2012 The Canadian Society of Clinical Chemists.-
dc.languageeng-
dc.relation.ispartofClinical Biochemistry-
dc.subjectHigh-sensitivity C-reactive protein (hs-CRP)-
dc.subjectMyeloperoxidase (MPO)-
dc.subjectLipocalin-2 (LCN2)-
dc.subjectMatrix metalloproteinase 9 (MMP9)-
dc.subjectMortality-
dc.subjectStroke-
dc.titleMultiple atherosclerosis-related biomarkers associated with short- and long-term mortality after stroke-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.clinbiochem.2012.06.014-
dc.identifier.pmid22728010-
dc.identifier.scopuseid_2-s2.0-84868301692-
dc.identifier.volume45-
dc.identifier.issue16-17-
dc.identifier.spage1308-
dc.identifier.epage1315-
dc.identifier.eissn1873-2933-
dc.identifier.isiWOS:000311064200007-
dc.identifier.issnl0009-9120-

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