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Article: Brain structural abnormalities in obsessive-compulsive disorder: Converging evidence from white matter and grey matter

TitleBrain structural abnormalities in obsessive-compulsive disorder: Converging evidence from white matter and grey matter
Authors
KeywordsVoxel-based morphometry
Obsessive-compulsive disorder
Meta-analysis
Diffusion tensor imaging
Issue Date2012
Citation
Asian Journal of Psychiatry, 2012, v. 5, n. 4, p. 290-296 How to Cite?
AbstractIntroduction: Specific cortico-striato-thalamic circuits are hypothesised to underlie the aetiology of obsessive-compulsive disorder (OCD). However, findings from neuroimaging studies have been inconsistent. In the current study, we attempted to provide a complete overview of structural alterations in OCD by conducting signed differential mapping (SDM) meta-analysis on grey matter and white matter studies of patients with OCD based on voxel-based morphometry (VBM) studies and diffusion tensor imaging (DTI) studies. Methods: Fifteen VBM and seven DTI case-control studies were included in this meta-analysis. SDM meta-analyses were performed to assess grey matter volume and white matter integrity changes in OCD patients and healthy controls. Results: We found that OCD patients had smaller grey matter volume than health controls in the frontal eye fields, medial frontal gyrus and anterior cingulate cortex. However, we showed that there was an increase in the grey matter volume in the lenticular nucleus, caudate nucleus and a small region in the right superior parietal lobule. OCD patients also had a lower fractional anisotropy (FA) in the cingulum bundles, inferior fronto-occipital fasciculus, and superior longitudinal fasciculus, while increased FA in the left uncinate fasciculus. Conclusions: The current findings confirm the structural abnormalities of cortico-striato-thalamic circuits in OCD. © 2012 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/292742
ISSN
2020 Impact Factor: 3.543
2020 SCImago Journal Rankings: 0.793
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPeng, Zi Wen-
dc.contributor.authorLui, Simon S.Y.-
dc.contributor.authorCheung, Eric F.C.-
dc.contributor.authorJin, Zhen-
dc.contributor.authorMiao, Guo Dong-
dc.contributor.authorJing, Jin-
dc.contributor.authorChan, Raymond C.K.-
dc.date.accessioned2020-11-17T14:57:07Z-
dc.date.available2020-11-17T14:57:07Z-
dc.date.issued2012-
dc.identifier.citationAsian Journal of Psychiatry, 2012, v. 5, n. 4, p. 290-296-
dc.identifier.issn1876-2018-
dc.identifier.urihttp://hdl.handle.net/10722/292742-
dc.description.abstractIntroduction: Specific cortico-striato-thalamic circuits are hypothesised to underlie the aetiology of obsessive-compulsive disorder (OCD). However, findings from neuroimaging studies have been inconsistent. In the current study, we attempted to provide a complete overview of structural alterations in OCD by conducting signed differential mapping (SDM) meta-analysis on grey matter and white matter studies of patients with OCD based on voxel-based morphometry (VBM) studies and diffusion tensor imaging (DTI) studies. Methods: Fifteen VBM and seven DTI case-control studies were included in this meta-analysis. SDM meta-analyses were performed to assess grey matter volume and white matter integrity changes in OCD patients and healthy controls. Results: We found that OCD patients had smaller grey matter volume than health controls in the frontal eye fields, medial frontal gyrus and anterior cingulate cortex. However, we showed that there was an increase in the grey matter volume in the lenticular nucleus, caudate nucleus and a small region in the right superior parietal lobule. OCD patients also had a lower fractional anisotropy (FA) in the cingulum bundles, inferior fronto-occipital fasciculus, and superior longitudinal fasciculus, while increased FA in the left uncinate fasciculus. Conclusions: The current findings confirm the structural abnormalities of cortico-striato-thalamic circuits in OCD. © 2012 Elsevier B.V.-
dc.languageeng-
dc.relation.ispartofAsian Journal of Psychiatry-
dc.subjectVoxel-based morphometry-
dc.subjectObsessive-compulsive disorder-
dc.subjectMeta-analysis-
dc.subjectDiffusion tensor imaging-
dc.titleBrain structural abnormalities in obsessive-compulsive disorder: Converging evidence from white matter and grey matter-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ajp.2012.07.004-
dc.identifier.pmid23174435-
dc.identifier.scopuseid_2-s2.0-84869874468-
dc.identifier.hkuros320835-
dc.identifier.volume5-
dc.identifier.issue4-
dc.identifier.spage290-
dc.identifier.epage296-
dc.identifier.eissn1876-2026-
dc.identifier.isiWOS:000218329100002-
dc.identifier.issnl1876-2018-

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