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Article: Promoting immunity during chronic infection-The therapeutic potential of common gamma-chain cytokines

TitlePromoting immunity during chronic infection-The therapeutic potential of common gamma-chain cytokines
Authors
Toe, Jesse G.Pellegrini, MarcMak, Tak Wah
KeywordsHIV
Cytokines
Infection
CD8 T cell +
Therapy
Common gamma-chain
Issue Date2013
Citation
Molecular Immunology, 2013, v. 56, n. 1-2, p. 38-47 How to Cite?
DOI: http://dx.doi.org/10.1016/j.molimm.2013.04.008
AbstractThe continued global burden wrought by chronic infectious disease is unrelenting. Current therapies have curbed the severity of disease for patients, but Human Immunodeficiency Virus (HIV) and Hepatitis B (HBV) infection remain incurable and Mycobacterium tuberculosis (MTB) is rapidly becoming resistant to our existing antibiotics. Much attention has been given to enhancing T cell immunity through the use of certain common gamma-chain cytokines, which have proven to be essential and necessary for T cell survival and function. This article reviews the pre-clinical and clinical literature surrounding IL-2, IL-7, IL-15 and IL-21 and we comment on the potential therapeutic promise of these cytokines as adjuvant treatments for chronic infectious diseases. © 2013 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/292749
ISSN
0161-5890
2021 Impact Factor: 4.174
2020 SCImago Journal Rankings: 1.291
ISI Accession Number ID
WOS:000321882800005

 

DC FieldValueLanguage
dc.contributor.authorToe, Jesse G.-
dc.contributor.authorPellegrini, Marc-
dc.contributor.authorMak, Tak Wah-
dc.date.accessioned2020-11-17T14:57:08Z-
dc.date.available2020-11-17T14:57:08Z-
dc.date.issued2013-
dc.identifier.citationMolecular Immunology, 2013, v. 56, n. 1-2, p. 38-47-
dc.identifier.issn0161-5890-
dc.identifier.urihttp://hdl.handle.net/10722/292749-
dc.description.abstractThe continued global burden wrought by chronic infectious disease is unrelenting. Current therapies have curbed the severity of disease for patients, but Human Immunodeficiency Virus (HIV) and Hepatitis B (HBV) infection remain incurable and Mycobacterium tuberculosis (MTB) is rapidly becoming resistant to our existing antibiotics. Much attention has been given to enhancing T cell immunity through the use of certain common gamma-chain cytokines, which have proven to be essential and necessary for T cell survival and function. This article reviews the pre-clinical and clinical literature surrounding IL-2, IL-7, IL-15 and IL-21 and we comment on the potential therapeutic promise of these cytokines as adjuvant treatments for chronic infectious diseases. © 2013 Elsevier Ltd.-
dc.languageeng-
dc.relation.ispartofMolecular Immunology-
dc.subjectHIV-
dc.subjectCytokines-
dc.subjectInfection-
dc.subjectCD8 T cell +-
dc.subjectTherapy-
dc.subjectCommon gamma-chain-
dc.titlePromoting immunity during chronic infection-The therapeutic potential of common gamma-chain cytokines-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.molimm.2013.04.008-
dc.identifier.pmid23685259-
dc.identifier.scopuseid_2-s2.0-84877893902-
dc.identifier.volume56-
dc.identifier.issue1-2-
dc.identifier.spage38-
dc.identifier.epage47-
dc.identifier.eissn1872-9142-
dc.identifier.isiWOS:000321882800005-
dc.identifier.issnl0161-5890-

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