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Article: Early time-dependent dynamic changes of TBET and GATA3 mRNA expressions in patients with acute coronary syndrome

TitleEarly time-dependent dynamic changes of TBET and GATA3 mRNA expressions in patients with acute coronary syndrome
Authors
Issue Date2013
Citation
Disease Markers, 2013, v. 35, n. 5, p. 419-429 How to Cite?
AbstractBackground. T-box expressed in T cells (TBET) and guanine adenine thymine adenine sequence-binding protein 3 (GATA3) play important roles in the differentiation of Th1 and Th2 subsets, which contributes to the progression of acute coronary syndrome (ACS). Objective. This study aimed to investigate the temporal change of TBET/GATA3 mRNA ratio in ACS. Methods. Thirtythree patients suspected of ACS with symptom onset within 24 hours were recruited. Blood samples were taken after arrival at the emergency department and at hourly intervals until the 6th hour. Them RNA expressions of TBET and GATA3 were quantified by a real-time RT-qPCR. Results. The TBET/GATA3mRNA ratio was elevated dramatically in patients with acutemyocardial infarction (AMI) and exhibited biphasic M-shaped release kinetics with two distinct peaks. The ratio was elevated 2 hours after symptom onset, dropped to the lowest level at 10 hours, and rose to the second peak at 14 hours. A similar biphasic M-shaped curve was observed in AMI patients with blood samples taken prior to any intervention. Conclusions. The TBET/GATA3 mRNA ratio was elevated in AMI patients throughout most of the first 20 hours after symptom onset. The biphasic M-shaped release kinetics was more likely to reflect pathophysiological changes rather than treatment effects. Copyright © 2013 Peter Kruzliak et al.
Persistent Identifierhttp://hdl.handle.net/10722/292792
ISSN
2021 Impact Factor: 3.464
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRainer, Timothy H.-
dc.contributor.authorGraham, Colin A.-
dc.contributor.authorChan, Rebecca W.Y.-
dc.contributor.authorChan, Cangel P.Y.-
dc.contributor.authorTan, Patrick C.F.-
dc.contributor.authorYip, Gabriel W.K.-
dc.contributor.authorYu, Cheuk Man-
dc.date.accessioned2020-11-17T14:57:13Z-
dc.date.available2020-11-17T14:57:13Z-
dc.date.issued2013-
dc.identifier.citationDisease Markers, 2013, v. 35, n. 5, p. 419-429-
dc.identifier.issn0278-0240-
dc.identifier.urihttp://hdl.handle.net/10722/292792-
dc.description.abstractBackground. T-box expressed in T cells (TBET) and guanine adenine thymine adenine sequence-binding protein 3 (GATA3) play important roles in the differentiation of Th1 and Th2 subsets, which contributes to the progression of acute coronary syndrome (ACS). Objective. This study aimed to investigate the temporal change of TBET/GATA3 mRNA ratio in ACS. Methods. Thirtythree patients suspected of ACS with symptom onset within 24 hours were recruited. Blood samples were taken after arrival at the emergency department and at hourly intervals until the 6th hour. Them RNA expressions of TBET and GATA3 were quantified by a real-time RT-qPCR. Results. The TBET/GATA3mRNA ratio was elevated dramatically in patients with acutemyocardial infarction (AMI) and exhibited biphasic M-shaped release kinetics with two distinct peaks. The ratio was elevated 2 hours after symptom onset, dropped to the lowest level at 10 hours, and rose to the second peak at 14 hours. A similar biphasic M-shaped curve was observed in AMI patients with blood samples taken prior to any intervention. Conclusions. The TBET/GATA3 mRNA ratio was elevated in AMI patients throughout most of the first 20 hours after symptom onset. The biphasic M-shaped release kinetics was more likely to reflect pathophysiological changes rather than treatment effects. Copyright © 2013 Peter Kruzliak et al.-
dc.languageeng-
dc.relation.ispartofDisease Markers-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleEarly time-dependent dynamic changes of TBET and GATA3 mRNA expressions in patients with acute coronary syndrome-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2013/139895-
dc.identifier.pmid24223457-
dc.identifier.pmcidPMC3810123-
dc.identifier.scopuseid_2-s2.0-84890386626-
dc.identifier.volume35-
dc.identifier.issue5-
dc.identifier.spage419-
dc.identifier.epage429-
dc.identifier.eissn1875-8630-
dc.identifier.isiWOS:000325981200001-
dc.identifier.issnl0278-0240-

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