File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1038/cddis.2014.126
- Scopus: eid_2-s2.0-84897400038
- PMID: 24675472
- WOS: WOS:000333754100058
Supplementary
- Citations:
- Appears in Collections:
Article: Survivin is essential for fertile egg production and female fertility in mice
Title | Survivin is essential for fertile egg production and female fertility in mice |
---|---|
Authors | |
Keywords | Apoptosis Granulosa cell Folliculogenesis Survivin Meiosis Oocyte |
Issue Date | 2014 |
Citation | Cell Death and Disease, 2014, v. 5, n. 3, article no. e1154 How to Cite? |
Abstract | Survivin is the smallest member of the inhibitor of apoptosis protein (IAP) family and acts as a bifunctional protein involved in mitosis regulation and apoptosis inhibition. To identify the physiological role of Survivin in female reproduction, we selectively disrupted Survivin expression in oocytes and granulosa cells (GCs), two major cell types in the ovary, by two different Cre-Loxp conditional knockout systems, and found that both led to defective female fertility. Survivin deletion in oocytes did not affect oocyte growth, viability and ovulation, but caused tetraploid egg production and thus female infertility. Further exploration revealed that Survivin was essential for regulating proper meiotic spindle organization, spindle assembly checkpoint activity, timely metaphase-to-anaphase transition and cytokinesis. Mutant mice with Survivin depleted in GCs showed reduced ovulation and subfertility, caused by defective follicular growth, increased follicular atresia and impaired luteinization. These findings suggest that Survivin has an important role in regulating folliculogenesis and oogenesis in the adult mouse ovary. |
Persistent Identifier | http://hdl.handle.net/10722/292815 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jiang, Z. Z. | - |
dc.contributor.author | Hu, M. W. | - |
dc.contributor.author | Wang, Z. B. | - |
dc.contributor.author | Huang, L. | - |
dc.contributor.author | Lin, F. | - |
dc.contributor.author | Qi, S. T. | - |
dc.contributor.author | Ouyang, Y. C. | - |
dc.contributor.author | Fan, H. Y. | - |
dc.contributor.author | Schatten, H. | - |
dc.contributor.author | Mak, T. W. | - |
dc.contributor.author | Sun, Q. Y. | - |
dc.date.accessioned | 2020-11-17T14:57:16Z | - |
dc.date.available | 2020-11-17T14:57:16Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Cell Death and Disease, 2014, v. 5, n. 3, article no. e1154 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292815 | - |
dc.description.abstract | Survivin is the smallest member of the inhibitor of apoptosis protein (IAP) family and acts as a bifunctional protein involved in mitosis regulation and apoptosis inhibition. To identify the physiological role of Survivin in female reproduction, we selectively disrupted Survivin expression in oocytes and granulosa cells (GCs), two major cell types in the ovary, by two different Cre-Loxp conditional knockout systems, and found that both led to defective female fertility. Survivin deletion in oocytes did not affect oocyte growth, viability and ovulation, but caused tetraploid egg production and thus female infertility. Further exploration revealed that Survivin was essential for regulating proper meiotic spindle organization, spindle assembly checkpoint activity, timely metaphase-to-anaphase transition and cytokinesis. Mutant mice with Survivin depleted in GCs showed reduced ovulation and subfertility, caused by defective follicular growth, increased follicular atresia and impaired luteinization. These findings suggest that Survivin has an important role in regulating folliculogenesis and oogenesis in the adult mouse ovary. | - |
dc.language | eng | - |
dc.relation.ispartof | Cell Death and Disease | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Apoptosis | - |
dc.subject | Granulosa cell | - |
dc.subject | Folliculogenesis | - |
dc.subject | Survivin | - |
dc.subject | Meiosis | - |
dc.subject | Oocyte | - |
dc.title | Survivin is essential for fertile egg production and female fertility in mice | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/cddis.2014.126 | - |
dc.identifier.pmid | 24675472 | - |
dc.identifier.pmcid | PMC3973204 | - |
dc.identifier.scopus | eid_2-s2.0-84897400038 | - |
dc.identifier.volume | 5 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | article no. e1154 | - |
dc.identifier.epage | article no. e1154 | - |
dc.identifier.eissn | 2041-4889 | - |
dc.identifier.isi | WOS:000333754100058 | - |
dc.identifier.issnl | 2041-4889 | - |