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Article: Neurological soft signs are not "soft" in brain structure and functional networks: Evidence from ALE meta-analysis

TitleNeurological soft signs are not "soft" in brain structure and functional networks: Evidence from ALE meta-analysis
Authors
Keywordsactivation
neurological
imaging
signs
meta-analysis
soft
likelihood
psychosis
estimation
schizophrenia
brain
Issue Date2014
Citation
Schizophrenia Bulletin, 2014, v. 40, n. 3, p. 626-641 How to Cite?
AbstractBackground: Neurological soft signs (NSS) are associated with schizophrenia and related psychotic disorders. NSS have been conventionally considered as clinical neurological signs without localized brain regions. However, recent brain imaging studies suggest that NSS are partly localizable and may be associated with deficits in specific brain areas. Method: We conducted an activation likelihood estimation meta-analysis to quantitatively review structural and functional imaging studies that evaluated the brain correlates of NSS in patients with schizophrenia and other psychotic disorders. Six structural magnetic resonance imaging (sMRI) and 15 functional magnetic resonance imaging (fMRI) studies were included. Results: The results from meta-analysis of the sMRI studies indicated that NSS were associated with atrophy of the precentral gyrus, the cerebellum, the inferior frontal gyrus, and the thalamus. The results from meta-analysis of the fMRI studies demonstrated that the NSS-related task was significantly associated with altered brain activation in the inferior frontal gyrus, bilateral putamen, the cerebellum, and the superior temporal gyrus. Conclusions: Our findings from both sMRI and fMRI meta-analyses further support the conceptualization of NSS as a manifestation of the "cerebello-thalamo-prefrontal" brain network model of schizophrenia and related psychotic disorders. © The Author 2013. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/292820
ISSN
2020 Impact Factor: 9.306
2020 SCImago Journal Rankings: 3.823
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhao, Qing-
dc.contributor.authorLi, Zhi-
dc.contributor.authorHuang, Jia-
dc.contributor.authorYan, Chao-
dc.contributor.authorDazzan, Paola-
dc.contributor.authorPantelis, Christos-
dc.contributor.authorCheung, Eric F.C.-
dc.contributor.authorLui, Simon S.Y.-
dc.contributor.authorChan, Raymond C.K.-
dc.date.accessioned2020-11-17T14:57:17Z-
dc.date.available2020-11-17T14:57:17Z-
dc.date.issued2014-
dc.identifier.citationSchizophrenia Bulletin, 2014, v. 40, n. 3, p. 626-641-
dc.identifier.issn0586-7614-
dc.identifier.urihttp://hdl.handle.net/10722/292820-
dc.description.abstractBackground: Neurological soft signs (NSS) are associated with schizophrenia and related psychotic disorders. NSS have been conventionally considered as clinical neurological signs without localized brain regions. However, recent brain imaging studies suggest that NSS are partly localizable and may be associated with deficits in specific brain areas. Method: We conducted an activation likelihood estimation meta-analysis to quantitatively review structural and functional imaging studies that evaluated the brain correlates of NSS in patients with schizophrenia and other psychotic disorders. Six structural magnetic resonance imaging (sMRI) and 15 functional magnetic resonance imaging (fMRI) studies were included. Results: The results from meta-analysis of the sMRI studies indicated that NSS were associated with atrophy of the precentral gyrus, the cerebellum, the inferior frontal gyrus, and the thalamus. The results from meta-analysis of the fMRI studies demonstrated that the NSS-related task was significantly associated with altered brain activation in the inferior frontal gyrus, bilateral putamen, the cerebellum, and the superior temporal gyrus. Conclusions: Our findings from both sMRI and fMRI meta-analyses further support the conceptualization of NSS as a manifestation of the "cerebello-thalamo-prefrontal" brain network model of schizophrenia and related psychotic disorders. © The Author 2013. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved.-
dc.languageeng-
dc.relation.ispartofSchizophrenia Bulletin-
dc.subjectactivation-
dc.subjectneurological-
dc.subjectimaging-
dc.subjectsigns-
dc.subjectmeta-analysis-
dc.subjectsoft-
dc.subjectlikelihood-
dc.subjectpsychosis-
dc.subjectestimation-
dc.subjectschizophrenia-
dc.subjectbrain-
dc.titleNeurological soft signs are not "soft" in brain structure and functional networks: Evidence from ALE meta-analysis-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/schbul/sbt063-
dc.identifier.pmid23671197-
dc.identifier.pmcidPMC3984512-
dc.identifier.scopuseid_2-s2.0-84898953047-
dc.identifier.hkuros320141-
dc.identifier.volume40-
dc.identifier.issue3-
dc.identifier.spage626-
dc.identifier.epage641-
dc.identifier.eissn1745-1701-
dc.identifier.isiWOS:000334750800021-
dc.identifier.issnl0586-7614-

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