File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1038/ki.2014.205
- Scopus: eid_2-s2.0-84926142468
- PMID: 24918157
- WOS: WOS:000345616900016
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: TREM-1 regulates macrophage polarization in ureteral obstruction
Title | TREM-1 regulates macrophage polarization in ureteral obstruction |
---|---|
Authors | |
Keywords | Chronic kidney disease Fibrosis Immunology and pathology Macrophages Obstructive nephropathy |
Issue Date | 2014 |
Citation | Kidney International, 2014, v. 86, n. 6, p. 1174-1186 How to Cite? |
Abstract | © 2014 International Society of Nephrology. Chronic kidney disease (CKD) is an emerging worldwide public health problem. Inflammatory cell infiltration and activation during the early stages in injured kidneys is a common pathologic feature of CKD. Here, we determined whether an important inflammatory regulator, triggering receptor expressed on myeloid cells (TREM)-1, is upregulated in renal tissues collected from mouse ureteral obstruction-induced nephritis. TREM-1 is crucial for modulating macrophage polarization, and has a pivotal role in mediating tubular injury and interstitial collagen deposition in obstructive nephritis. Lysates from nephritic kidneys triggered a TREM-1-dependent M1 polarization ex vivo, consistent with the observation that granulocyte-macrophage colony-stimulating factor (GM-CSF)-derived M1 macrophages express higher levels of TREM-1 in comparison with M-CSF-derived cells. Moreover, agonistic TREM-1 cross-link significantly strengthens the inductions of iNOS and GM-CSF in M1 cells. These observations are validated by a strong clinical correlation between infiltrating TREM-1-expressing/iNOS-positive macrophages and renal injury in human obstructive nephropathy. Thus, TREM-1 may be a potential diagnostic and therapeutic target in human kidney disease. |
Persistent Identifier | http://hdl.handle.net/10722/292871 |
ISSN | 2023 Impact Factor: 14.8 2023 SCImago Journal Rankings: 3.886 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lo, Tzu Han | - |
dc.contributor.author | Tseng, Kai Yu | - |
dc.contributor.author | Tsao, Wen Shan | - |
dc.contributor.author | Yang, Chih Ya | - |
dc.contributor.author | Hsieh, Shie Liang | - |
dc.contributor.author | Chiu, Allen Wen Hsiang | - |
dc.contributor.author | Takai, Toshiyuki | - |
dc.contributor.author | Mak, Tak W. | - |
dc.contributor.author | Tarng, Der Cherng | - |
dc.contributor.author | Chen, Nien Jung | - |
dc.date.accessioned | 2020-11-17T14:57:23Z | - |
dc.date.available | 2020-11-17T14:57:23Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Kidney International, 2014, v. 86, n. 6, p. 1174-1186 | - |
dc.identifier.issn | 0085-2538 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292871 | - |
dc.description.abstract | © 2014 International Society of Nephrology. Chronic kidney disease (CKD) is an emerging worldwide public health problem. Inflammatory cell infiltration and activation during the early stages in injured kidneys is a common pathologic feature of CKD. Here, we determined whether an important inflammatory regulator, triggering receptor expressed on myeloid cells (TREM)-1, is upregulated in renal tissues collected from mouse ureteral obstruction-induced nephritis. TREM-1 is crucial for modulating macrophage polarization, and has a pivotal role in mediating tubular injury and interstitial collagen deposition in obstructive nephritis. Lysates from nephritic kidneys triggered a TREM-1-dependent M1 polarization ex vivo, consistent with the observation that granulocyte-macrophage colony-stimulating factor (GM-CSF)-derived M1 macrophages express higher levels of TREM-1 in comparison with M-CSF-derived cells. Moreover, agonistic TREM-1 cross-link significantly strengthens the inductions of iNOS and GM-CSF in M1 cells. These observations are validated by a strong clinical correlation between infiltrating TREM-1-expressing/iNOS-positive macrophages and renal injury in human obstructive nephropathy. Thus, TREM-1 may be a potential diagnostic and therapeutic target in human kidney disease. | - |
dc.language | eng | - |
dc.relation.ispartof | Kidney International | - |
dc.subject | Chronic kidney disease | - |
dc.subject | Fibrosis | - |
dc.subject | Immunology and pathology | - |
dc.subject | Macrophages | - |
dc.subject | Obstructive nephropathy | - |
dc.title | TREM-1 regulates macrophage polarization in ureteral obstruction | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1038/ki.2014.205 | - |
dc.identifier.pmid | 24918157 | - |
dc.identifier.scopus | eid_2-s2.0-84926142468 | - |
dc.identifier.volume | 86 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 1174 | - |
dc.identifier.epage | 1186 | - |
dc.identifier.eissn | 1523-1755 | - |
dc.identifier.isi | WOS:000345616900016 | - |
dc.identifier.issnl | 0085-2538 | - |