File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1111/cei.12621
- Scopus: eid_2-s2.0-84930414955
- PMID: 25753260
- WOS: WOS:000355844500005
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Thymic stromal lymphopoietin deficiency attenuates experimental autoimmune encephalomyelitis
Title | Thymic stromal lymphopoietin deficiency attenuates experimental autoimmune encephalomyelitis |
---|---|
Authors | |
Keywords | TSLP EAE Autoimmunity T cells |
Issue Date | 2015 |
Citation | Clinical and Experimental Immunology, 2015, v. 181, n. 1, p. 51-64 How to Cite? |
Abstract | © 2015 British Society for Immunology. In the present study we examined the role of thymic stromal lymphopoietin (TSLP) in experimental autoimmune encephalomyelitis (EAE). Here, we report that TSLP knock-out (KO) mice display a delayed onset of disease and an attenuated form of EAE. This delayed onset was accompanied by a reduced number of encephalitogenic T helper type 1 (Th1) cells in the central nervous system (CNS) of TSLP KO mice. In addition, CD4+ and CD8+ T cells from CNS of TSLP KO mice show a reduced activation status in comparison to wild-type mice. It is noteworthy that we could also show that lymph node cells from TSLP KO mice expanded less efficiently and that interleukin (IL)-6-, interferon (IFN)-γ and tumour necrosis factor (TNF)-α levels were reduced. Furthermore, CD3+ T cells isolated in the preclinical phase from myelin oligodendrocyte glycoprotein peptide 35-55 (MOG35-55)-immunized TSLP KO mice showed a reduced response after secondary exposure to MOG35-55, indicating that differentiation of naive T cells into MOG35-55-specific effector and memory T cells was impaired in KO mice. The addition of recombinant TSLP enhanced T cell proliferation during MOG35-55 restimulation, showing that T cells also respond directly to TSLP. In summary, these data demonstrate that expression of, and immune activation by, TSLP contributes significantly to the immunopathology of EAE. |
Persistent Identifier | http://hdl.handle.net/10722/292889 |
ISSN | 2023 Impact Factor: 3.4 2023 SCImago Journal Rankings: 1.114 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Eckhardt, J. | - |
dc.contributor.author | Döbbeler, M. | - |
dc.contributor.author | König, C. | - |
dc.contributor.author | Kuczera, K. | - |
dc.contributor.author | Kuhnt, C. | - |
dc.contributor.author | Ostalecki, C. | - |
dc.contributor.author | Zinser, E. | - |
dc.contributor.author | Mak, T. W. | - |
dc.contributor.author | Steinkasserer, A. | - |
dc.contributor.author | Lechmann, M. | - |
dc.date.accessioned | 2020-11-17T14:57:26Z | - |
dc.date.available | 2020-11-17T14:57:26Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Clinical and Experimental Immunology, 2015, v. 181, n. 1, p. 51-64 | - |
dc.identifier.issn | 0009-9104 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292889 | - |
dc.description.abstract | © 2015 British Society for Immunology. In the present study we examined the role of thymic stromal lymphopoietin (TSLP) in experimental autoimmune encephalomyelitis (EAE). Here, we report that TSLP knock-out (KO) mice display a delayed onset of disease and an attenuated form of EAE. This delayed onset was accompanied by a reduced number of encephalitogenic T helper type 1 (Th1) cells in the central nervous system (CNS) of TSLP KO mice. In addition, CD4+ and CD8+ T cells from CNS of TSLP KO mice show a reduced activation status in comparison to wild-type mice. It is noteworthy that we could also show that lymph node cells from TSLP KO mice expanded less efficiently and that interleukin (IL)-6-, interferon (IFN)-γ and tumour necrosis factor (TNF)-α levels were reduced. Furthermore, CD3+ T cells isolated in the preclinical phase from myelin oligodendrocyte glycoprotein peptide 35-55 (MOG35-55)-immunized TSLP KO mice showed a reduced response after secondary exposure to MOG35-55, indicating that differentiation of naive T cells into MOG35-55-specific effector and memory T cells was impaired in KO mice. The addition of recombinant TSLP enhanced T cell proliferation during MOG35-55 restimulation, showing that T cells also respond directly to TSLP. In summary, these data demonstrate that expression of, and immune activation by, TSLP contributes significantly to the immunopathology of EAE. | - |
dc.language | eng | - |
dc.relation.ispartof | Clinical and Experimental Immunology | - |
dc.subject | TSLP | - |
dc.subject | EAE | - |
dc.subject | Autoimmunity | - |
dc.subject | T cells | - |
dc.title | Thymic stromal lymphopoietin deficiency attenuates experimental autoimmune encephalomyelitis | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1111/cei.12621 | - |
dc.identifier.pmid | 25753260 | - |
dc.identifier.pmcid | PMC4469155 | - |
dc.identifier.scopus | eid_2-s2.0-84930414955 | - |
dc.identifier.volume | 181 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 51 | - |
dc.identifier.epage | 64 | - |
dc.identifier.eissn | 1365-2249 | - |
dc.identifier.isi | WOS:000355844500005 | - |
dc.identifier.issnl | 0009-9104 | - |