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Article: The neural basis of olfactory function and its relationship with anhedonia in individuals with schizotypy: An exploratory study

TitleThe neural basis of olfactory function and its relationship with anhedonia in individuals with schizotypy: An exploratory study
Authors
KeywordsAnhedonia
Olfaction
Schizotypy
Imaging
Issue Date2015
Citation
Psychiatry Research: Neuroimaging, 2015, v. 234, n. 2, p. 202-207 How to Cite?
Abstract© 2015 Elsevier Ireland Ltd. Previous studies have established a linkage between olfactory deficits and negative symptoms in schizophrenia. However, it is not known whether olfactory function is associated with hedonic traits in individuals with schizotypy. Seventeen individuals with schizotypy and 18 age- and sex-matched controls participated in this study. Hedonic traits were assessed with the Chapman Scales for Physical and Social Anhedonia (CSAS and CPAS). Olfactory function was assessed with the Sniffin' Stick Test (olfactory threshold, odour discrimination and odour identification). All participants undertook a structural imaging scan for grey matter volume measurements. Individuals with schizotypy had significantly higher CSAS and CPAS scores than healthy controls. They had normal olfactory function. Their odour identification ability was inversely correlated with physical and social anhedonia. The volume of the right parahippocampal gyrus was positively associated with odour identification ability, and negatively associated with physical and social anhedonia. Furthermore, mediation analysis suggested that odour identification ability influences anhedonia through its effect on the right parahippocampal gyrus. No such relationship was found in controls. These findings suggest that there is a relationship between odour identification and anhedonia in individuals with schizotypy, and the association may be mediated by parahippocampal gyrus volume.
Persistent Identifierhttp://hdl.handle.net/10722/292912
ISSN
2023 Impact Factor: 2.1
2023 SCImago Journal Rankings: 0.797
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZou, Lai quan-
dc.contributor.authorGeng, Fu lei-
dc.contributor.authorLiu, Wen hua-
dc.contributor.authorWei, Xin hua-
dc.contributor.authorJiang, Xin qing-
dc.contributor.authorWang, Yi-
dc.contributor.authorShi, Hai song-
dc.contributor.authorLui, Simon S.Y.-
dc.contributor.authorCheung, Eric F.C.-
dc.contributor.authorChan, Raymond C.K.-
dc.date.accessioned2020-11-17T14:57:29Z-
dc.date.available2020-11-17T14:57:29Z-
dc.date.issued2015-
dc.identifier.citationPsychiatry Research: Neuroimaging, 2015, v. 234, n. 2, p. 202-207-
dc.identifier.issn0925-4927-
dc.identifier.urihttp://hdl.handle.net/10722/292912-
dc.description.abstract© 2015 Elsevier Ireland Ltd. Previous studies have established a linkage between olfactory deficits and negative symptoms in schizophrenia. However, it is not known whether olfactory function is associated with hedonic traits in individuals with schizotypy. Seventeen individuals with schizotypy and 18 age- and sex-matched controls participated in this study. Hedonic traits were assessed with the Chapman Scales for Physical and Social Anhedonia (CSAS and CPAS). Olfactory function was assessed with the Sniffin' Stick Test (olfactory threshold, odour discrimination and odour identification). All participants undertook a structural imaging scan for grey matter volume measurements. Individuals with schizotypy had significantly higher CSAS and CPAS scores than healthy controls. They had normal olfactory function. Their odour identification ability was inversely correlated with physical and social anhedonia. The volume of the right parahippocampal gyrus was positively associated with odour identification ability, and negatively associated with physical and social anhedonia. Furthermore, mediation analysis suggested that odour identification ability influences anhedonia through its effect on the right parahippocampal gyrus. No such relationship was found in controls. These findings suggest that there is a relationship between odour identification and anhedonia in individuals with schizotypy, and the association may be mediated by parahippocampal gyrus volume.-
dc.languageeng-
dc.relation.ispartofPsychiatry Research: Neuroimaging-
dc.subjectAnhedonia-
dc.subjectOlfaction-
dc.subjectSchizotypy-
dc.subjectImaging-
dc.titleThe neural basis of olfactory function and its relationship with anhedonia in individuals with schizotypy: An exploratory study-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.pscychresns.2015.09.011-
dc.identifier.pmid26404551-
dc.identifier.scopuseid_2-s2.0-84946475745-
dc.identifier.hkuros320784-
dc.identifier.volume234-
dc.identifier.issue2-
dc.identifier.spage202-
dc.identifier.epage207-
dc.identifier.eissn1872-7506-
dc.identifier.isiWOS:000365053600007-
dc.identifier.issnl0925-4927-

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