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Article: Prognostic values of 4 risk scores in Chinese patients with chest pain: Prospective 2-centre cohort study

TitlePrognostic values of 4 risk scores in Chinese patients with chest pain: Prospective 2-centre cohort study
Authors
KeywordsChinese
Emergency department
Risk stratification
Prognostic
Cardiac
Score
Predictive
MACE
Thrombolysis in myocardial infarction
Global registry for acute coronary event
Chest pain
Banach
HEART
Issue Date2016
Citation
Medicine (United States), 2016, v. 95, n. 52, article no. e4778 How to Cite?
AbstractCopyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. Four risk scores for stratifying patients with chest pain presenting to emergency departments (EDs) (namely Thrombolysis in myocardial infarction [TIMI], Global registry for acute coronary events [GRACE], Banach and HEART) have been developed in Western settings but have never been compared and validated in Chinese patients. We aimed to find out to the number of MACE within 7 days, 30 days, and 6 months after initial ED presentation, and also to compare the prognostic performance of these scores in Chinese patients with suspected cardiac chest pain (CCP) to predict 7-day, 30-day, and 6-month major adverse cardiac events (MACE). A prospective 2-center observational cohort study of consecutive patients presenting with chest pain to the EDs of 2 university hospitals in Guangdong and Hong Kong from 17 March 2012 to 14 August 2013 was conducted. Patients aged ≥18 years with suspected CCP but without ST-segment elevation myocardial infarction (STEMI) were recruited. Of 833 enrolled patients (mean age 65.1 years, SD14.5; 55.6% males), 121 (14.5%) experienced MACE within 6 months (4.8% with safety outcomes and 10.3% with effectiveness outcomes). The HEART score had the largest area under the receiver operating characteristic (ROC) curve for predicting MACE at 7-day, 30-day, and 6-month follow-up [area under curve (AUC)=0.731, 0.726, and 0.747, respectively. The HEART score also had the largest AUC for predicting effectiveness outcome (AUC=0.715, 0.704, and 0.721, respectively). However, there was no significant difference in AUC between HEART and TIMI scores. Banach had the largest AUC for predicting safety outcome (AUC=0.856, 0.837, and 0.850, respectively). The HEART score performed better than the GRACE and Banach scores to predict total MACE and effectiveness outcome in Chinese patients with suspected CCP, whereas the Banach score best predicted safety outcomes.
Persistent Identifierhttp://hdl.handle.net/10722/292994
ISSN
2021 Impact Factor: 1.817
2020 SCImago Journal Rankings: 0.590
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, Xiao Hui-
dc.contributor.authorJiang, Hui Lin-
dc.contributor.authorLi, Yun Mei-
dc.contributor.authorChan, Cangel Pui Yee-
dc.contributor.authorMo, Jun Rong-
dc.contributor.authorTian, Chao Wei-
dc.contributor.authorLin, Pei Yi-
dc.contributor.authorGraham, Colin A.-
dc.contributor.authorRainer, Timothy H.-
dc.date.accessioned2020-11-17T14:57:39Z-
dc.date.available2020-11-17T14:57:39Z-
dc.date.issued2016-
dc.identifier.citationMedicine (United States), 2016, v. 95, n. 52, article no. e4778-
dc.identifier.issn0025-7974-
dc.identifier.urihttp://hdl.handle.net/10722/292994-
dc.description.abstractCopyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. Four risk scores for stratifying patients with chest pain presenting to emergency departments (EDs) (namely Thrombolysis in myocardial infarction [TIMI], Global registry for acute coronary events [GRACE], Banach and HEART) have been developed in Western settings but have never been compared and validated in Chinese patients. We aimed to find out to the number of MACE within 7 days, 30 days, and 6 months after initial ED presentation, and also to compare the prognostic performance of these scores in Chinese patients with suspected cardiac chest pain (CCP) to predict 7-day, 30-day, and 6-month major adverse cardiac events (MACE). A prospective 2-center observational cohort study of consecutive patients presenting with chest pain to the EDs of 2 university hospitals in Guangdong and Hong Kong from 17 March 2012 to 14 August 2013 was conducted. Patients aged ≥18 years with suspected CCP but without ST-segment elevation myocardial infarction (STEMI) were recruited. Of 833 enrolled patients (mean age 65.1 years, SD14.5; 55.6% males), 121 (14.5%) experienced MACE within 6 months (4.8% with safety outcomes and 10.3% with effectiveness outcomes). The HEART score had the largest area under the receiver operating characteristic (ROC) curve for predicting MACE at 7-day, 30-day, and 6-month follow-up [area under curve (AUC)=0.731, 0.726, and 0.747, respectively. The HEART score also had the largest AUC for predicting effectiveness outcome (AUC=0.715, 0.704, and 0.721, respectively). However, there was no significant difference in AUC between HEART and TIMI scores. Banach had the largest AUC for predicting safety outcome (AUC=0.856, 0.837, and 0.850, respectively). The HEART score performed better than the GRACE and Banach scores to predict total MACE and effectiveness outcome in Chinese patients with suspected CCP, whereas the Banach score best predicted safety outcomes.-
dc.languageeng-
dc.relation.ispartofMedicine (United States)-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectChinese-
dc.subjectEmergency department-
dc.subjectRisk stratification-
dc.subjectPrognostic-
dc.subjectCardiac-
dc.subjectScore-
dc.subjectPredictive-
dc.subjectMACE-
dc.subjectThrombolysis in myocardial infarction-
dc.subjectGlobal registry for acute coronary event-
dc.subjectChest pain-
dc.subjectBanach-
dc.subjectHEART-
dc.titlePrognostic values of 4 risk scores in Chinese patients with chest pain: Prospective 2-centre cohort study-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1097/MD.0000000000004778-
dc.identifier.pmid28033243-
dc.identifier.pmcidPMC5207539-
dc.identifier.scopuseid_2-s2.0-85010214331-
dc.identifier.volume95-
dc.identifier.issue52-
dc.identifier.spagearticle no. e4778-
dc.identifier.epagearticle no. e4778-
dc.identifier.eissn1536-5964-
dc.identifier.isiWOS:000391628200001-
dc.identifier.issnl0025-7974-

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