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Article: Neural mechanism and heritability of complex motor sequence and audiovisual integration: A healthy twin study

TitleNeural mechanism and heritability of complex motor sequence and audiovisual integration: A healthy twin study
Authors
Keywordsfist-edge-palm
heritability
audiovisual integration
fMRI
healthy twin
Issue Date2018
Citation
Human Brain Mapping, 2018, v. 39, n. 3, p. 1438-1448 How to Cite?
Abstract© 2017 Wiley Periodicals, Inc. Complex motor sequencing and sensory integration are two key items in scales assessing neurological soft signs. However, the underlying neural mechanism and heritability of these two functions is not known. Using a healthy twin design, we adopted two functional brain imaging tasks focusing on fist-edge-palm (FEP) complex motor sequence and audiovisual integration (AVI). Fifty-six monozygotic twins and 56 dizygotic twins were recruited in this study. The pre- and postcentral, temporal and parietal gyri, the supplementary motor area, and the cerebellum were activated during the FEP motor sequence, whereas the precentral, temporal, and fusiform gyri, the thalamus, and the caudate were activated during AVI. Activation in the supplementary motor area during FEP motor sequence and activation in the precentral gyrus and the thalamic nuclei during AVI exhibited significant heritability estimates, ranging from 0.5 to 0.62. These results suggest that activation in cortical motor areas, the thalamus and the cerebellum associated with complex motor sequencing and audiovisual integration function may be heritable.
Persistent Identifierhttp://hdl.handle.net/10722/293066
ISSN
2020 Impact Factor: 5.038
2020 SCImago Journal Rankings: 2.005
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Zhi-
dc.contributor.authorHuang, Jia-
dc.contributor.authorXu, Ting-
dc.contributor.authorWang, Ya-
dc.contributor.authorLi, Ke-
dc.contributor.authorZeng, Ya Wei-
dc.contributor.authorLui, Simon S.Y.-
dc.contributor.authorCheung, Eric F.C.-
dc.contributor.authorJin, Zhen-
dc.contributor.authorDazzan, Paola-
dc.contributor.authorGlahn, David C.-
dc.contributor.authorChan, Raymond C.K.-
dc.date.accessioned2020-11-17T14:57:48Z-
dc.date.available2020-11-17T14:57:48Z-
dc.date.issued2018-
dc.identifier.citationHuman Brain Mapping, 2018, v. 39, n. 3, p. 1438-1448-
dc.identifier.issn1065-9471-
dc.identifier.urihttp://hdl.handle.net/10722/293066-
dc.description.abstract© 2017 Wiley Periodicals, Inc. Complex motor sequencing and sensory integration are two key items in scales assessing neurological soft signs. However, the underlying neural mechanism and heritability of these two functions is not known. Using a healthy twin design, we adopted two functional brain imaging tasks focusing on fist-edge-palm (FEP) complex motor sequence and audiovisual integration (AVI). Fifty-six monozygotic twins and 56 dizygotic twins were recruited in this study. The pre- and postcentral, temporal and parietal gyri, the supplementary motor area, and the cerebellum were activated during the FEP motor sequence, whereas the precentral, temporal, and fusiform gyri, the thalamus, and the caudate were activated during AVI. Activation in the supplementary motor area during FEP motor sequence and activation in the precentral gyrus and the thalamic nuclei during AVI exhibited significant heritability estimates, ranging from 0.5 to 0.62. These results suggest that activation in cortical motor areas, the thalamus and the cerebellum associated with complex motor sequencing and audiovisual integration function may be heritable.-
dc.languageeng-
dc.relation.ispartofHuman Brain Mapping-
dc.subjectfist-edge-palm-
dc.subjectheritability-
dc.subjectaudiovisual integration-
dc.subjectfMRI-
dc.subjecthealthy twin-
dc.titleNeural mechanism and heritability of complex motor sequence and audiovisual integration: A healthy twin study-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/hbm.23935-
dc.identifier.pmid29266498-
dc.identifier.pmcidPMC6866262-
dc.identifier.scopuseid_2-s2.0-85041708636-
dc.identifier.hkuros320728-
dc.identifier.volume39-
dc.identifier.issue3-
dc.identifier.spage1438-
dc.identifier.epage1448-
dc.identifier.eissn1097-0193-
dc.identifier.isiWOS:000424804400029-
dc.identifier.issnl1065-9471-

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