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Article: Therapeutic effects of Qianlie Tongli decoction on chronic prostatitis/chronic pelvic pain syndrome induced by peptide T2 in mice

TitleTherapeutic effects of Qianlie Tongli decoction on chronic prostatitis/chronic pelvic pain syndrome induced by peptide T2 in mice
Authors
Keywordstherapeutic effects
TCM formula
chronic prostatitis
chronic pelvic pain syndrome
immunization
Issue Date2020
Citation
Journal of Pharmacy and Pharmacology, 2020, v. 72, n. 10, p. 1436-1444 How to Cite?
Abstract© 2020 Royal Pharmaceutical Society Objectives: This study was undertaken to reveal therapeutic effects and the preliminary mechanism of Chinese medicine formula Qianlie Tongli decoction (QTD) in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Methods: A total of 50 male C57BL/6 mice were randomly divided into five groups. All groups except the control group were injected subcutaneously T2 peptide emulsion, which induced the CP/CPPS model. After the induction of CP/CPPS, the model group was given normal saline by oral gavage while low-dose, medium-dose and high-dose groups were treated with Chinese medicine formula. Micturition habits and pain behaviour of mice were analysed for each group. Haematoxylin and eosin (H&E) staining was used to investigate prostate inflammation. The serum level of tumour necrosis factor-α (TNF-α) was measured by enzyme-linked immunosorbent assay (ELISA) kit. Key findings: Chinese medicine formula significantly reduced the number of urine spots and improved pain response frequency in the medium-dose and high-dose group. The high-dose group showed reduced considerably inflammatory lesion and inflammatory cell infiltration than the low-dose and medium-dose groups. Serum levels of TNF-α in the high-dose group were significantly reduced compared with the model group. Conclusions: The results demonstrated the therapeutic effects of Qianlie Tongli decoction in CP/CPPS mice by analysing clinically relevant symptoms (urinary tract system, pelvic pain and prostate inflammation) and preliminarily explored the inflammatory-related treatment mechanisms by measuring TNF-α.
Persistent Identifierhttp://hdl.handle.net/10722/293133
ISSN
2023 Impact Factor: 2.8
2023 SCImago Journal Rankings: 0.648
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCui, Xingxing-
dc.contributor.authorNaveed, Muhammad-
dc.contributor.authorBaig, Mirza Muhammad Faran Ashraf-
dc.contributor.authorWang, Wenlu-
dc.contributor.authorMikrani, Reyaj-
dc.contributor.authorLiu, Ziwei-
dc.contributor.authorAhmad, Bilal-
dc.contributor.authorTang, Meng-
dc.contributor.authorWazir, Junaid-
dc.contributor.authorZhou, Xiaohui-
dc.contributor.authorHan, Lei-
dc.date.accessioned2020-11-19T09:02:03Z-
dc.date.available2020-11-19T09:02:03Z-
dc.date.issued2020-
dc.identifier.citationJournal of Pharmacy and Pharmacology, 2020, v. 72, n. 10, p. 1436-1444-
dc.identifier.issn0022-3573-
dc.identifier.urihttp://hdl.handle.net/10722/293133-
dc.description.abstract© 2020 Royal Pharmaceutical Society Objectives: This study was undertaken to reveal therapeutic effects and the preliminary mechanism of Chinese medicine formula Qianlie Tongli decoction (QTD) in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Methods: A total of 50 male C57BL/6 mice were randomly divided into five groups. All groups except the control group were injected subcutaneously T2 peptide emulsion, which induced the CP/CPPS model. After the induction of CP/CPPS, the model group was given normal saline by oral gavage while low-dose, medium-dose and high-dose groups were treated with Chinese medicine formula. Micturition habits and pain behaviour of mice were analysed for each group. Haematoxylin and eosin (H&E) staining was used to investigate prostate inflammation. The serum level of tumour necrosis factor-α (TNF-α) was measured by enzyme-linked immunosorbent assay (ELISA) kit. Key findings: Chinese medicine formula significantly reduced the number of urine spots and improved pain response frequency in the medium-dose and high-dose group. The high-dose group showed reduced considerably inflammatory lesion and inflammatory cell infiltration than the low-dose and medium-dose groups. Serum levels of TNF-α in the high-dose group were significantly reduced compared with the model group. Conclusions: The results demonstrated the therapeutic effects of Qianlie Tongli decoction in CP/CPPS mice by analysing clinically relevant symptoms (urinary tract system, pelvic pain and prostate inflammation) and preliminarily explored the inflammatory-related treatment mechanisms by measuring TNF-α.-
dc.languageeng-
dc.relation.ispartofJournal of Pharmacy and Pharmacology-
dc.subjecttherapeutic effects-
dc.subjectTCM formula-
dc.subjectchronic prostatitis-
dc.subjectchronic pelvic pain syndrome-
dc.subjectimmunization-
dc.titleTherapeutic effects of Qianlie Tongli decoction on chronic prostatitis/chronic pelvic pain syndrome induced by peptide T2 in mice-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/jphp.13325-
dc.identifier.pmid32648958-
dc.identifier.scopuseid_2-s2.0-85087713093-
dc.identifier.hkuros320907-
dc.identifier.volume72-
dc.identifier.issue10-
dc.identifier.spage1436-
dc.identifier.epage1444-
dc.identifier.eissn2042-7158-
dc.identifier.isiWOS:000546708100001-
dc.identifier.issnl0022-3573-

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